凝血与弥散性血管内凝血ppt课件.pptVIP

REGULATION OF COAGULATION/DISSEMINATED INTRAVASCULAR COAGULATION * REGULATION OF COAGULATIONIntroduction Coagulation necessary for maintenanceof vascular integrity Enough fibrinogen to clot all vessels What controls clotting process? * COAGULATION CASCADE Va/Xa/PL VIIIa/IXa/PL or VIIa/TF FXII FXIIa TF FVII FG F HMWK FXI FXIa VIIa/TF or FVIIa Ca+2 FIX FIXa Ca+2 Ca+2 Ca+2 VIII VIIIa T V Va T Ca+2 FX FXa Ca+2 Ca+2 PT T Common Pathway Middle Components Surface Active Components INTRINSIC PATHWAY EXTRINSIC PATHWAY * COAGULATION INHIBITORS Tissue Factor Pathway Inhibitor (TFPI) Lipoprotein Assoc