哮喘的小气道炎症.ppt

Nieto A,et al. Montelukast improves pulmonary function measure d by impulse oscillometry in children with asthma (Mio study).Respir Med.2006 Jul;100(7):1180-5. As Xrs5（distal capacitive reactance） reactance has usually negative values, increases are associated with improvement. * Spahn JD,et al. Effect of montelukast on peripheral airflow obstruction in children with asthma. Ann Allergy Asthma Immunol. 2006;96:541-549. 随机双盲，空白对照。21例9-18岁轻中度哮喘儿童，孟鲁司特/安慰剂治疗8周 研究指标：Raw，RV，FEV1 等 随机入组时无论RV还是残气量/肺总量（RV/TLC），孟鲁司特组和安慰剂组的差异都是不显著的。 治疗完成时，使用孟鲁司特治疗组RV和RV/TLC都有显著下降，说明气体闭陷得到明显改善。 * Nakaji H, et al. Effects of 24-week add-on treatment with ciclesonide and montelukast on small airways inflammation in asthma. Ann Allergy Asthma Immunol. 2013 Mar;110(3):198-203.e3 This was a randomized, open-label, parallel comparison study of 24-week add-on treatment with either inhaled ciclesonide or montelukast. * Nakaji H, et al. Effects of 24-week add-on treatment with ciclesonide and montelukast on small airways inflammation in asthma. Ann Allergy Asthma Immunol. 2013 Mar;110(3):198-203.e3 Figure 3. Alveolar nitric oxide concentrations in the 3 study groups. Asterisk indicates significant difference in the time trends for alveolar nitric oxide concentrations among the 3 treatment modalities ( P=0.048, by 2-way analysis of variance [ANOVA]). Dagger indicates significant changes in alveolar nitric oxide concentrations in the ciclesonide add-on group ( P=0.03 vs the control group, by 2-way ANOVA) (P=0.01, by 1-way ANOVA). Double dagger indicates significant changes within montelukast add-on group (P=0.01, by 1-way ANOVA). Figure 4. Reactance area (AX) levels in the 3 study groups. Asterisk indicates significant difference in the time trends for AX levels among the 3 treatment modalities (P=0.04, by 2-way analysis of variance [ANOVA]). Daggerindicates post hoc analysis between the montelukast add-on and control groups (P=0.05, by 2-way ANOVA). * Nakaji H, et al. Effects of 24-week add-on trea