beclin1 pten在子宫颈鳞癌中表达 相关性及意义word格式论文.docxVIP

CINI,CINII-III, and UCSCC,; Expressions of Beclin1 and PTEN tend to decreasement alonge in the development of cervical cance, and the difference was significant ( P 0.05);2，The expression of Beclin1 in CINI（X2=12.846 P=0.000）,CINII-III （X2=22.209P=0.000）and UCSCC（X2=44.096 P=0.000）respectively was a significant difference with in the normal cervix; CINI was a significant difference with in uterine cervical squmous cell carcinomas（X2=33.345 P=0.001），and CINII-III was a significant difference with in uterinecervical squmous cell carcinomas（X2=23.450 P=0.000）;3，The expression of PTEN in CINI（X2=9.943 P=0.000）,CINII-III(X2=15.421P=0.000）and UCSCC（X2=22.340P=0.000）respectively was a significant difference with in the normal cervix; LSILwas a significant difference with in UCSCC（X2=11.148P=0.001）；4, Loss of Beclin1 protein expression was associated with tumor differentiation（X2=16.045P=0.000）and pelvic lymph node metastasi（sX2=5.441P=0.029）and cervicalinvasion（X2=4.568P=0.041）, Loss of PTEN protein expression was associated with tumordifferentiatio（nX2=10.518P=0.002）and pelvic lymph node metastasi（sX2=5.541P=0.031）,but they were not related with patient age,FIGO stage, cervical tumor size(P0.05).5,The expression of Beclin1 and PTEN protein was extremely positively correlated in the cervical carcinoma (rs=0.900, P0.01）.Conclusion1. Along with pathogenetie condition progression，the expressions of Beclin1 andPTEN tended to reduce, .The results suggest that the expressing changes of Beclin1 and PTEN may activate the oncogene and play an important role in the happen of cervical tumor.The expression of Beclin1 in CINI was a significant difference with in uterine cervical squmous cell carcinomas，and CINII-III was a significant difference with in uterine cervical squmous cell carcinomas; The expression of PTEN in CINIwas a significant differencewith in UCSCC,The results show Beclin1 and PTEN might provide help to early diagnose cervical squamous cell cancer.Loss of B