bmscs对糖尿病创面pmns和mφ浸润及其趋化因子表达影响的分析word格式论文.docxVIP

优秀毕业论文 精品参考文献资料 缩略语表 英文缩写 BMSCs英文全称 bone marrow mesenchymal stem cells中文全称 骨髓间充质干细胞PMNneutrophil中性粒细胞MΦmacrophage巨噬细胞MIP-2macrophage inflammatory protein-2巨噬细胞炎症蛋白 2MCP-1monocyte chemotactic protein-1单核细胞趋化蛋白 1PBSPhosphate buffer saline磷酸盐缓冲液mRNAMessenger Ribonucleic Acid信使核糖核酸ODOptical Density光密度CODCorrected Optical Density校正光密度RT-qPCRreal-time quantitative polymerase chain reaction荧光定量聚合酶链反应MHCMajor Histocompatibility Complex主要组织相容性抗原VEGFvascular endothelial growth factor细胞血管内皮生长因子FGFFibroblast Growth Factor成纤维细胞生长因子HGFHepatocyte Growth Factor肝细胞生长因子IGFInsulin-like Growth Factor胰岛素样生长因子PDGFplatelet derived growth factor血小板源性生长因子DMSOdimethylsulfoxide二甲基亚砜EDTAEthylene Diamine Tetraacetic Acid乙二胺四乙酸IBMX3 isobutyl 1methylxanthine异丁基甲基黄嘌呤HEHaematoxylin and eosin苏木素-伊红HRPHorse Radish Peroxidase辣根过氧化酶BSABovine Serum Albumin牛血清蛋白DEPCdiethylpyrocarbonate焦碳酸二乙酯cDNAcomplementary DNA互补脱氧核糖核酸ROSReactive oxygen species活性氧自由基 1  Study on effect of BMSCs on PMNs＆MΦ influx and their Chemokines expression in diabetic wound Abstract Background: With 90 million people living with diabetes and 1.3 million died in 2011, china has the largest diabetes epidemic in the world. More effective treatment was urged for diabetic Wound healing. Wound healing is initiated by early inflammatory cells and involves interaction and dual directional regulation of many cells and molecules. It was said that chronic subclinical inflammation in the skin of diabetics inhibits the acute inflammatory response, coursing inadequate and delayed influx PMNs and MΦ, contributing to impaired diabetic wound healing. Both domestic and abroad researches have shown that treatments restoring PMNs and MΦ influx in diabetic wounds early after injury tend to result in accelerated wound healing. Bone mesenchymal stem cells (BMSCs) are multipotent stem cells that hold promise for an expanding list of therapeutic uses. It wa