c57bl6.nodaec1aec2干燥综合征模型小鼠的眼表体征 组织病理学观察及发病机制的初步分析word格式论文.docxVIP

SPFSpecific pathogen-free无特定病原体SSSj?grens syndrome干燥综合征pSSPrimary sj?grens syndrome原发性干燥综合征sSSSecondary sj?grens syndrome继发性干燥综合征TGF-βTransforming growth factor-β转化生长因子-βTh cellT-helper cell辅助性 T 细胞TregRegulatory T cell调节性 T 细胞mRNAMessenger ribonucleic acid信使 RNAEvaluating the ocular surface signs, histopathology, and pathogenesis of a Sj?gren’s Syndrome mouse model: C57BL/6.NOD-Aec1Aec2 mouseAbstractSj?gren syndrome (SS) is a chronic autoimmune disease that mainly involves the salivary and lacrimal glands. It could be classified into secondary sj?gren syndrome (sSS) and primary sj?gren syndrome (pSS) according to other organs suffered or not. It has been studied that the incidence of SS is about 1% and the ratio of male to female is 1: 9. According to the 2007 International Dry Eye Disease Workshop (DEWS): inflammation of the ocular surface and hyperosmolar of tear film are key factors in the onset and development of dry eye. Sj?grens syndrome belongs to aqueous-deficient dry eye according to the pathology of dry eye.Recent years, many mouse models have been designed to investigate the mechanism of dry eye. Although the animal model showed decreased tear secretion and damaged ocular surface epithelium, the unstable and complex processes make them not perfectly mimic the characteristic of human dry eye, which is chronic, aggravated and repeated onset. If there is an animal model that could mimic human dry eye and show a chronic process so that researchers could study the mechanism of dry eye at different stages, it may be helpful to prevent, diagnose and treat dry eye and provide an useful animal model for clinical drug research.Non-obese (NOD) mouse is an animal model of autoimmune diabetes. It could develope pancreatitis spontaneously because of nineteen diabetes susceptibility loci (named Idd) on the chromosome. Although it could develop dry eye, it could not be reasoned from SS because of diabetes. It has been reported that two of the nineteen chromosomal interv