copd患者静息和运动时呼吸中枢驱动及其在吸入噻托溴铵后变化word格式论文.docxVIP

copd患者静息和运动时呼吸中枢驱动及其在吸入噻托溴铵后变化word格式论文.docx

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copd患者静息和运动时呼吸中枢驱动及其在吸入噻托溴铵后变化word格式论文

Neural respiratory drive during rest and exercise in COPD and the effect of Tiotropium inhalationAbstractBackgroundBronchodilators, the most commonly used drugs in COPD, have been shown to reduce dyspnea, improve exercise tolerance and improve health status. However, conventional lung function parameters such as forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) frequently fail to detect significant functional responses to bronchodilators in patients with chronic airflow obstruction. It is necessary for clinical and scientific reasons to develop a new tool to objectively assess the effect of different treatments including bronchodilator on COPD. Because dyspnea relates to respiratory effort, neural respiratory drive and its efficiency as expressed by a ratio of ventilation to the diaphragm electromyogram (EMGdi) may be useful to evaluate treatment benefits in Patients with COPD.Part 1.Neural respiratory drive during rest and constant treadmill exercise in COPD compared with healthyObjectiveDetermined whether efficiency of neural drive in patients with COPD is lower than that in healthy subjects, and whether it changes during exercise.Subjects and methodsWe studied 12 male patients with COPD (mean±SD age 62.8±10.3 years, FEV1 28.1±10.2% predicted) and 12 age- and gender-matched healthy subjects (age 61.1±7.2 years, FEV1 101.5±11.9% predicted). EMGdi was recorded from a multipair esophageal electrode during a constant work (80% of maximal oxygen consumption derived from a previous incremental exercise test) treadmill exercise. Minute ventilation (Ve) and oxygen consumption (VO2) were also measured. BorgScale and IC maneuver is performed at 1-minute interval during exercise.ResultsRoot mean square (RMS) of the EMGdi increased initially and reached a plateau at submaximal drive during constant load exercise in both COPD patients and healthy subjects. The ratio of ventilation to EMGdi remained stable during exercise in healthy subjects from be

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