cpgc41对tlrs信号通路的交互影响及其抗类风湿关节炎的初步分析word格式论文.docxVIP

缩略语表英文缩写 英文全称 中文全称bp base pair 碱基BSA Bovine serum albumin 牛血清白蛋白 CpG ODN unmethylated sequences of DNA TLR9 激动剂 d Day 天dd H2O double distillated water 双蒸水DMSO Dimethylsulfoxide 二甲基亚砜DOTAP 2-Dioleoyloxy-3-trimethylammonium propane 脂质转染剂dNTP deoxyribonucleoside triphosphate 脱氧核糖核苷三磷酸ELISA enzyme-linked immunosorbent assay 酶联免疫吸附法ERK extracellular signal regulated protein kinase 细胞外信号调节激酶G- Gram-negative 革兰阴性G+ Gram-positive 革兰阳性h Hour 小时HKLM Heat Killed Listeria monocytogenes TLR2 激动剂IκB Inhibitors of the NF-κB 核转录因子-κB 抑制蛋白IL interleukin 白细胞介素IFN Interferon 干扰素LBP lipopolysaccharide-binding protein 内毒素结合蛋白LPS Lipopolysaccharide 内毒素(脂多糖)JNK c-Junamino terminal kinase c-jun 氨基末端激酶M molar concentration 摩尔浓度MAPK mitogen-activated protein kinases 丝裂原活化蛋白激酶mCD14 membrane CD14 膜 CD14min Minute 分钟ml milliliter 毫升NF-κBp38 Pam3CSK4Nuclear factor-kappa B p38 proteinSynthetic triacylated lipoprotein核转录因子-κB丝氨酸/苏氨酸蛋白激酶TLR1/2 激动剂PAMPs PBSpoly(I:C)pathogen-associated molecular patterns phosphate buffered salinePolyinosinic-polycytidylic acid病原体相关分子模式磷酸盐缓冲液TLR3 激动剂PRRspattern recognition receptors模式识别受体RARnaseRheumatoid ArthritisRibonucleaseRA RNA 酶rpm Real-time PCRsecrevolutions per minute Real-time polymerase chain reactionSecond转/分逆转录多聚酶链式反应 秒ssRNA TLRTNF-αSingle strand RNA Toll-like receptortumor necrosis factor alphaTLR7 激动剂Toll 样受体 肿瘤坏死因子 αTRAF6TrisTNFR-associated factor 6Tri(hydroxymethyl)aminomethane肿瘤坏死因子受体相关因子三羟甲基氨基甲烷Cross-interference of CpG-c41 on TLRs pathway and its protection against the Rheumatoid Arthritis miceAbstractToll-like receptors (TLRs), body’s innate immune system’s pattern recognition receptors (PRRs), specifically recognizing and combining with corresponding pathogen- associated molecular patterns (PAMPs), therefore activate the host innate immune response. Although different TLRs always track a relative independent signal pathway, these pathways can be cross-connected each other and thus form a signal transduction network, inducing complicated