皮细胞钠离子通道.PDFVIP

APEPTICO FORSCHUNG UND ENTWICKLUNG GMBH APEPTICO Forschung und Entwicklung GmbH Mariahilferstraße 136, Top 1.15 A-1150 Vienna, Austria T: +43 664 1432919 E: b.fischer@ W: APEPTICO 是一家私人拥有的生物技术公司，以肽为 APEPTICO is a privately-held biotechnology company, developing peptide-based products 基础开发针对慢性和威胁生命的疾病的产品。肽分子对 targeting chronic and life-threatening diseases. The 应经过验证的药效学活性结构，以及知名的蛋白质结构 peptide molecules correspond to validated, 域和药用生物分子。通过专注于合成的蛋白质结构， pharmacodynamic active structures and domains of APEPTICO 能够避免基因和细胞技术带来的相关风 well-known proteins and biopharmaceuticals. By concentrating on synthetically produced protein 险。APEPTICO 利用其技术平台PEPBASE （TM ）和 structures, APEPTICO avoids general risks PEPSCREEN （TM ），显著降低了成本并缩短了产品 associated with gene- and cell-technologies. 的上市时间。 APEPTICO makes use of its technology platforms PEPBASE(TM) and PEPSCREEN(TM) to significantly reduce cost and to shorten time to market. APEPTICO 开发了AP301 肽家族。AP301 肽是水溶 性的分子，可以通过口服吸入到肺部。 APEPTICO develops the AP301 peptide family. 制成的AP301 容易 AP301 peptides are water soluble molecules and can 雾化。AP301 和衍 be administered into the lung by oral inhalation. 生肽是为了激活肺上 Formulated AP301 is easily nebulised. AP301 and derived peptides are designed for activation of the 皮细胞钠离子通道 pulmonary epithelial sodium channel (ENaC). （ENaC）而设计 Activation of ENaC by AP301 results in an 的。用AP301 激活 accelerated lung oedema clearance in the airspace. ENaC 会加速清除肺 AP301 peptides are effective in therape