基于超声弹性成像技术的生物组织应变估计算法仿真分析-simulation analysis of biological tissue strain estimation algorithm based on ultrasonic elastography technology.docxVIP

AbstractThe elastic properties of soft tissues depend on their molecular building blocks, and on the microscopic and macroscopic structural organization of these blocks. The changes in tissues’ elastic properties are correlated with pathological changes as well. So there are some differences in stiffness between the lesion and the surrounding normal tissue. Be imposed on with an incentive, biological soft tissue has a deformation, so we can obtain the pre- and postcompression RF signals and estimate the displacement distribution of tissue, and then get the strain distribution and elastic modulus distribution of biological soft tissue by means of signal processingandcross-correlation.Basedonthereflection-typeultrasound elastography system, the thesis put forward a 1-D axial strain estimation method, which can accurately estimate the elastic modulus (or hardness) distribution of biological soft tissue. The main work of the thesis is as follows:Firstly, it introduces one fundamental mechanics law of biological soft tissue in ultrasound elastography – Hooke’s law, and studies mechanical properties of biological soft tissue and that elastography is applied in the tissue so that simplify it to build the mechanical model of biological tissue in elastography. It introduces the principle of ultrasonic elastography and some most common elastographies and ultrasound elastography system and its classifications based on the principle of ultrasonic elastography of quasi-static or static compression, and studies on the imaging principle of reflection-type ultrasonic elastography system compared with transmission-type ultrasonic elastography system.Secondly, it studies on cross-correlation algorithm, a classical algorithm for ultrasonic elastography, and traditional time-domain cross-correlation algorithm based on cross-correlation algorithm. Considering the deficiencies of traditional methods, the thesis puts forward a method of computing scaling