基于废物最小的o,s-二甲基硫代磷酰胺连续生产过程开发-development of continuous production process of o, s - dimethyl phosphorothioate based on waste minimization.docx

optimized on the objective of the total yield of O,O-dimethylphosphorochlorido- thioate with complex methods optimization by MATLAB.When the stage of ser- ies is increased, the ratio of recycle is reduced, the reaction temperature is do- wn,the quality and the yield of product is rised. The quality can reach 94.35% and the yield can reach above 93.86% in optimal conditionswhen six stages recycle tubular reactors in series. The pilot-scale experimental result of one re- cycle tubular reactor agrees well with the calculation value by model. It provi- des guide for designing and optimizing the equipment inindustrial producing process.The ammonolysis reaction kinetics of O,O-dimethylphosphorochloridothioate without catalyst was studied. The model showes that the effects of the initial mole ratio between ammonia and acyl chloride, concentration of ammonia and temperature on the reaction rate are very obvious. In addition, the effect of concentration of acyl chloride on the rate of ammonolysis is very small.The reaction rate demonstrates the pseudo-first order to ammonia during early period of reaction and the second order to ammonia and acyl halide during the late period. A new green process is proposed to produce O,O-dialkyl phosphoroamidothioate continuously by recycle tubular reactor with the analysis of waste minimization and the study of reaction kinetics. 25kt/y of recycle tubular reactor was built .It is indicated that the quality and the yield of product is rised 0.74% and 2.93% individually. The production capacity of one set equipment is 7 times compared with batch reactor.It can decrease a great deal of energy consumption.The isomerization reactionkinetic of O,O-dialkyl phosphoroamidothioate was studied by simplex optimization.The rate of isomerization behaves the first order to dimethyl sulphate and O,O-dialkyl phosphoroamidothioate individuall