SCD-HeFT Use of R-R interval statistics for long-term risk stratification for arrhythmic sudden cardiac death_Image_Marked资料.pdf

SCD-HeFT: Use of R-R interval statistics for long-term risk stratification for arrhythmic sudden cardiac death * * * Wan-tai M. Au-yeung, MSc, Per G. Reinhall, PhD, Jeanne E. Poole, MD, Jill Anderson, RN, BSN,† George Johnson, BSEE,† Ross D. Fletcher, MD,‡ Hans J. Moore, MD, FHRS,‡ Daniel B. Mark, MD, MPh,§ Kerry L. Lee, PhD,§ Gust H. Bardy, MD*† From the *University of Washington, Seattle, Washington, †Seattle Institute for Cardiac Research, Seattle, Washington, ‡Washington DC Veterans Administration Medical Center, Washington, District of Columbia, and §Duke University, Durham, North Carolina. BACKGROUND In the Sudden Cardiac Death in Heart Failure Trial CONCLUSION Predictor variables extracted from R-R intervals (SCD-HeFT), a significant fraction of the patients with congestive correlate to the occurrences of SCD and distinguish survival heart failure ultimately did not die suddenly of arrhythmic causes. functions among patients with ICDs in SCD-HeFT. We believe Patients with CHF will benefit from better tools to identify if that SCD prediction models should incorporate Holter-based implantable cardioverter-defibrillator (ICD) therapy is needed. R-R interval analysis to refine ICD patient selection, especially to exclude patients who are unlikely to benefit from ICD OBJECTIVES We aimed to identify predictor variables from base- therapy. line SCD-HeFT patients’ R-R intervals that correlate to arrhythmic sudden cardiac death (SCD) and mortality and to design an ICD KEYWORDS Sudden cardiac death; Implantable