加减三甲散对肝纤维化大鼠肝组织tgf-β1mrna及α-sma表达的影响-effects of modified sanjiasan on tgf - β 1 mrna and α sma expression in liver tissue of rats with hepatic fibrosis.docxVIP

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加减三甲散对肝纤维化大鼠肝组织tgf-β1mrna及α-sma表达的影响-effects of modified sanjiasan on tgf - β 1 mrna and α sma expression in liver tissue of rats with hepatic fibrosis.docx

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加减三甲散对肝纤维化大鼠肝组织tgf-β1mrna及α-sma表达的影响-effects of modified sanjiasan on tgf - β 1 mrna and α sma expression in liver tissue of rats with hepatic fibrosis

reticulum expansion, mitochondria swelling, collagen hyperplasia in the Dane’s space were observed in the model group. While pathologic changes in the treatment group was much better and the JJSJS group seems to be better than that of colchicines group. 3.Expression of TGF-β1mRNA in hepatic tissues: compared with the normal group, the model group showed higher expression of TGF-β1mRNA. While in the treatment group, its expression decreased significantly （P0.01）and the JJSJS group showed lower expression than that in the colchicines group（P0.05）. 4.Expression of α-SMA in hepatic tissues: expression of α-SMA was higher in the model group than that in the normal group, lower in the treatment group than that in the model group significantly （P0.01） and the JJSJS group showed lower expression than that in the colchicines group（P0.05） Conclusions: 1. JJSJS is helpful to improve the general health situation of rats in terms of activity, appetite, skin color and luster and body weight. 2.JJSJS reduces the fibrotic degree of rats hepatic tissue significantly which means that this formular has powerful anti-fibrosis effect. 3. JJSJS inhibits expression of TGF-β1mRNA in hepatic tissues by which it suppresses the activation, proliferation of HSC and the formation of collagens. This formula can also down regulate expression of α-SMA by which it reduces yield of extra-cellular matrix thus is effective to go against the liver fibrosis. Keywords: jiajiansanjiasan(JJSJS) ， hepatic fibrosis, TGF-β1mRNA, α-SMA 英文缩略词对照表缩略词英文全称中文全称 ACE-IBlood vessel tense element transformation enzyme inhibitor 血管紧张素转换酶抑制剂 ALBalbumin白蛋白 ALPAlkaline phosphatase碱性磷酸酶 ALTalanine amiotransferase 丙氨酸氨基转移酶 AP-1activator protein 1活化蛋白质 1 α-SMAalpha-sooth muscle actin a-平滑肌肌动蛋白 BSAbovine serum albumin牛血清白蛋白 CCL4carbon tetrachloride四氯化碳 Clchlorine氯 CDKCyclin dependent kinase细胞周期蛋白依赖性激酶 DABdiaminobenzidine二氨基联苯胺 DEPCDiethyl pyrocarbonate 焦碳酸二乙酯 ECM Extra-cellular matrix细胞外基质 ET Endothelin内皮素 FNFibr