卵巢上皮性癌血清CA125、CA724、Cu.ZnSOD测定的临床意义.docVIP

卵巢上皮性癌血清CA125、CA724、Cu.ZnSOD测定的临床意义 【关键词】 卵巢 摘要: 目的：探讨卵巢上皮性癌血清CA125、CA724、铜锌超氧化物歧化酶（Cu.ZnSOD）水平测定的临床意义。方法：采用放射免疫法测定42例卵巢上皮性癌患者、66例卵巢良性病变患者及15例正常对照血清CA125、CA724、Cu.ZnSOD水平，并对随访超过4个月的15例卵巢上皮性癌患者定期测定血清CA125、CA724、Cu.ZnSOD水平，同时对不同期别及有无残留癌灶的卵巢上皮性癌患者的各标记物水平进行了比较。结果： （1）卵巢上皮性癌组血清CA125、CA724、Cu.ZnSOD水平明显高于卵巢良性病变组(P0.05), 卵巢良性病变组明显高于正常对照组(P0.05)。（2）界值提高后的CA125和CA724联合测定对卵巢上皮性癌诊断价值最高，敏感性和特异性分别为88.0%和86.0%。（3）Ⅲ、Ⅳ期卵巢上皮性癌患者血清CA125、CA724水平高于Ⅰ、Ⅱ期(P0.05)。 （4）残留癌灶直径≤2 cm的卵巢上皮性癌患者血清CA125、CA724水平低于残留癌灶直径2 cm者(P0.05)。（5）卵巢上皮性癌血清CA125水平变化与病情变化呈正相关(P0.05)，相关系数rs=0.39，符合率为67.6%。（6）血清CA125、CA724联合检测预测复发的敏感性为100%, 先于临床复发3~4个月升高。结论：（1）血清CA125、CA724水平对卵巢上皮性癌的诊断有肯定价值，联合测定优于单项检测，尤以界值提高后联合检测为佳。（2）血清CA125水平动态检测可作为监测病情变化、判断疗效、反映肿瘤负荷的可靠指标。（3）血清CA125、CA724可提前临床3~4个月预测复发，两者联合敏感性达100%。（4）血清Cu.ZnSOD可提示卵巢存在病变。 关键词: 卵巢上皮性癌; CA125; CA724; 铜锌超氧化物歧化酶 Clinical value of serum CA125, CA724, and Cu.ZnSOD in epithelial ovarian cancer ZHANG Yunxia, LI Tingfang (Department of Gynecologic Oncology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, China) Abstract: Objective: To assess the value of serum CA125、CA724、and Cu.ZnSOD in diagnosis and management of ovarian cancer. Methods: CA125、CA724、and Cu.ZnSOD were measured using the radioimmunoassay. All markers were measured in 42 patients with proven epithelial ovarian cancer 、66 patients with benign ovarian disease and 15 healthy persons. CA125、CA724、and Cu.ZnSOD were measured in 15 patients with ovarian cancer who were submitted to surgical staging and cytoreduction followed by adjuvant platinum based chemotherapy over 4 courses. Results: The CA125、CA724 and Cu.ZnSOD levels of patients with proven epithelial ovarian cancer were higher than patients with benign ovarian disease ,and the CA125、CA724 and Cu.ZnSOD levels of patients with benign ovarian disease were higher than healthy persons. For these enhanced cutoff limits being 85U/ml for CA125, 4.8U/ml for CA724, the combination of CA125 with CA724 increased the sensitiviry to 88.0% and