卵巢恶性中胚叶混合瘤12例临床分析.docVIP

卵巢恶性中胚叶混合瘤12例临床分析 中华肿瘤杂志 1998年第6期第0卷 临床研究 作者：李洪君　石素胜　章文华 单位：100021 北京，中国医学科学院中国协和医科大学肿瘤医院妇科(李洪君、章文华)，病理科(石素胜) 　　关键词： 卵巢肿瘤/诊断；卵巢肿瘤/治疗；中胚叶混合瘤/诊断；中胚叶混合瘤/治疗 　　【摘要】　目的　探讨卵巢恶性中胚叶混合瘤的临床特点、治疗及预后因素。方法　对我院1983年～1997年收治的12例卵巢恶性中胚叶混合瘤的临床资料进行回顾性分析。按FIGO分期(1985年)，Ⅱ期4例，Ⅲ期6例，Ⅳ期1例，不详1例。组织学 　　Malignant mixed mesodermal tumors of the ovary: a clinical analysis of 12 cases　　emLi Hongjun, Shi Susheng, Zhang Wenhua, et al. Department of the Gynecology, Cancer Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100021 /em 　　【Abstract】　Objective　To explore the clinical characteristics, treatment and prognostic factors of patients with malignant mixed mesodermal tumors of the ovary (MMMTO).Methods Clinical data of 12 patients with MMMTO between 1983-1997 were reviewed retrospectively. The median age of the patients was 50.7 years. According to FIGO staging system (1985), there were 4 cases in stage Ⅱ, 6 in stage Ⅲ and 1 in stage Ⅳ. Staging was unclear in the remaining case. Heterologous and homologous elements were present in the primary ovarian tumors in 4 and 8 of the 12 patients, respectively. All patients received cytoreductive surgery. Eleven of them received postoperative chemotherapy and 3 of these eleven patients received additional radiotherapy of pelvic field.Results　 The median survival of this group of 12 patients was 24 months. The 2-and 5-year survival rate was 33.3%(4/12) and 8.33%(1/12), respectivcly. The 2-year survival rate of stage Ⅱ and Ⅲ was 50% and 33.3% respectively. One patent in stage Ⅳ died within 1 year. Four of the 8 patients with homologous histology survived over 2 years while all the 4 cases with heterologous histology died within 2 years. Five of the 11 patients (45.5%) received combination therapy died within 1 year while 1 patient treated with surgery alone died within 6 months.Conclusions The prognosis of MMMTO is rather poor. Surgery combined with chemotherapy and/or radiotherapy seems to be a better choice of approach. T