囊胚期与卵裂期胚胎移植的宫外孕发生率比较.docVIP

囊胚期与卵裂期胚胎移植的宫外孕发生率比较 【关键词】 囊胚期 【摘要】 目的 探讨囊胚期胚胎移植是否较卵裂期胚胎移植能减少体外受精与胚胎移植宫外孕的发生率。 方法 回顾性分析1999年1月～2003年12月在我所接受体外受精与胚胎移植助孕获临床妊娠的506例妇女，按胚胎移植的时间不同分为两组，其中采卵后120h囊胚期胚胎移植者为98例D5组，采卵后72h卵裂期胚胎移植者为408例D3组，比较两组宫外孕发生率。 结果 98例D5组中宫外孕11例（11.2%），408例D3组宫外孕38例（9.3%），两组之间宫外孕发生率差异无显著性（P0.05）。 结论 囊胚期胚胎移植并不能减少体外受精与胚胎移植的宫外孕发生率。 关键词 宫外孕 囊胚期 卵裂期 体外受精 胚胎移植 The comparison of ectopic pregnancy rates in blastocyst and cleavagestage embryo transfer in vitro fertilization Ye Hong，Huang Guoning Reproductive and Genetic Institute of Chongqing Obstetric and Gynecology Hospital，Chongqing400013. 【Abstract】 Objective To investigate if blastocyst stage embryo transfer can reduce the ectopic pregnancy rate compared with cleavage stage in vitro fertilization and embryo transfer（IVF-ET）treatment.Methods 506pregnant women received IVF-ET in our institute during Jan.1999to Dec.2003were retrospectively analyzed.The patients were divided into two groups according to the different day of embryo transfer after oocyte retrieved.98patients re-ceived blastocyst stage embryo transfers at120hours after oocyte retrieved were defined as D5group.408patients who transferred cleavage stage embryos at72hours were defined as D3group.The ectopic pregnancy rates were compared in the two groups.Results The ectopic pregnancy rate is11.2%（11/98）in D5group，with no difference compared with D3group in which the ectopic pregnancy rate is9.3%（38/408）.Conclusion In IVF-ET，patients cannot benefit from blastocyst stage embryo transfer on the aspect of ectopic pregnancy reduction as compared with cleavage stage embryo transfer. Key words ectopic pregnancy blastocyst stage cleavage stage in vitro fertilization embryo transfer 宫外孕是体外受精与胚胎移植（IVF-ET）中的重要并发症之一，在IVF-ET临床妊娠中发生率约2%～5% ［1］ ，但在单纯输卵管因素不孕的妇女中，经IVF-ET助孕后的宫外孕发生率可高达11% ［2］ ，明显高于自然妊娠的宫外孕发生率（1.2%～1.4%） ［3］ 。现回顾性分析1999年1月～2003年12月我所98例囊胚期胚胎移植与408例卵裂期胚胎移植宫外孕发生情况，以期了解囊胚期胚胎移植是否能减少IVF-ET后的宫外孕发生率。 1 对象与方法 1.1 研究对象 1999年1月～2003年12月在本所生殖中心接受常规体外受精/单精子卵细胞浆内显微注射与胚胎移植（IVF/ICSI-ET）获得临床妊娠的506例孕妇，按其