多囊卵巢综合征患者瘦素、雄激素、胰岛素关系临床研究.docVIP

多囊卵巢综合征患者瘦素、雄激素、胰岛素关系临床研究 作者：鲁晓燕,刘曼华,郑艳莉,陶潜 单位：南通大学第二附属医院妇产科，南通 226001 【摘要】 目的：通过研究多囊卵巢综合征(PCOS)患者血清瘦素(Leptin)、雄激素(T)、胰岛素(Ins)间关系，为临床辅助诊断及治疗提供理论依据。方法：选取PCOS患者55例为研究组，正常人群26例为对照组，均分成肥胖组与非肥胖组，同时PCOS患者随机分3组：A组服达英-35，B组达英-35+二甲双胍，C组曲谱瑞林，治疗3个月，均测定血清Leptin、T、Ins、黄体生成素(LH)、促卵泡素(FSH)水平，进行相关比较。结果：血清Leptin、Ins、T、LH水平PCOS组均高于相当体重指数对照组;且Leptin水平在肥胖组高于非肥胖组，Ins水平在PCOS组内肥胖组高于非肥胖组;PCOS患者血清瘦素、雄激素、胰岛素间呈正相关性;达英-35治疗组T、Leptin下降;达英-35+二甲双胍组T、Leptin、Ins均下降;曲谱瑞林组T下降显著，Leptin有下降，Ins水平虽有所下降，但差异无统计学意义;组间比较曲谱瑞林组T水平下降最显著。结论：PCOS患者存在高雄激素、高胰岛素、高瘦素血症，三者间呈正相关性;达英-35联合二甲双胍可降低患者血清雄激素、瘦素、胰岛素水平;对PCOS顽固性高雄激素及高瘦素者短期应用促性腺激素释放激素激动剂(GnRH-a)可能获得更好疗效。 【关键词】 多囊卵巢综合征;瘦素;雄激素;胰岛素 A clinical study on the correlation among leptin，testosterone and insulin in women with PCOS 　　LU Xiaoyan,LIU Manhua,ZHENG Yanli,et al (Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Nantong University, Nantong 226001) 　　[Abstract] Objective: To detect the correlation among Leptin, testosterone(T), and insulin(Ins) and to put forward theoretical supports to clinical subsidiary diagnosis and treatment for women with polycystic ovarian syndrome (PCOS).Methods: The subjects were 55 patients with PCOS and 26 normal control women, both of whom were classified into two groups: obesity group and non-obesity group. At the same time, the PCOS women were divided randomly into three groups: women in Group A were treated with Diane-35, in Group B with Diane-35+metformin and in Group C with Triptorelin for three months. In all patients, serum concentrations of hormone levels of leptin, T, Ins, LH,and FSH were measured to compare their relationship. Results: It was showed that serum leptin, Ins, T and LH than those in control group, both of which have the similar BMI. Whats more, higher level of serum leptin could be observed in obesitic group than those in non-obesitic one, . their levels of serum Leptin, Ins, T in women with PCOS were higher than those in normal control women. There was a positive correlation among seru