女性生殖道移行细胞癌及伴移行细胞癌分化肿瘤临床病理分析.docVIP

女性生殖道移行细胞癌及伴移行细胞癌分化肿瘤临床病理分析 作者：吕春燕1,杨开选2,陈鲜3,蔡建4 单位：1.四川省成都中医药大学附属医院病理科，四川 成都 610072;2.四川大学华西第二医院，四川 成都 610000;3.四川省成都市363医院，四川 成都 610000;4.四川省成都市第九人民医院，四川成都 610000 【摘要】目的：分析女性生殖道移行细胞癌(transitional cell carcinoma，TCC)及伴移行细胞癌分化肿瘤的临床、病理及免疫组化表达特征，探讨TCC的诊断和鉴别诊断及细胞分化。方法：收集17例发生于女性生殖道的TCC及伴TCC分化肿瘤的存档蜡块以及临床资料，对其进行临床病理形态学观察和免疫组化检测。结果：17例患者均为中老年人，肿瘤分别发生于卵巢12例，输卵管2例，子宫内膜2例，左卵巢转移至盆腔1例。临床症状主要为腹胀、腹痛、腹部包块，阴道流血等。随访时间6个月～4年3个月。健在7例，复发或转移2例，死亡4例，失访5例。大体表现为囊实性包块或实性包块，镜下见低级别尿路上皮癌改变，大多数TCC混合有其他组织学类型或为其他恶性肿瘤的伴随成分。免疫组织化学示15例作了CK7和CK20染色，15例均CK7阳性，CK20阴性。结论：女性生殖道的TCC及伴TCC分化肿瘤是女性生殖道恶性肿瘤的一种少见类型，各个部位都可发生，但以卵巢最多见，均具有独特的病理特征，是一种预后较好的恶性肿瘤。 【关键词】 女性生殖道;移行细胞癌;临床病理分析 Clinicopathologcal analysis of primary transitional cell carcinoma of female genital tract and tumor with transitional cell differentiation LV Chun-yan1，YANG Kai-xuan2，CHEN Xian3，et al (1.Department of Pathology，the Affiliated Hospital of Chengdu University of TCM，Chengdu 610000，China;2.West China Second Hospital，Sichuan University，Chengdu 610072，China;3.No.363 Hospital of Chengdu City，Chengdu 610000，China) 　　Abstract：ObjectiveTo explore the clinicopathologcal and immunohistochemistry expression features of primary transitional cell carcinoma of female genital tract and tumor with transitional cell differentiation，and analyze its diagnosis，differential diagnosis and cytodifferentiation.MethodParaffin block files and clinical data of 17 primary transitional cell carcinoma of female genital tract was collected.The histological features and immunohistochemical characteristics were investigated by light microscopy.ResultsAll of 17 were middle-old ages，12 located at ovaries，2 at fallopian tube，2 at endometrium，and 1 at pelvic cavity transfered from left ovary.Its major clinical symptoms included abdominal distension，pain and lump，vaginal profluvium sanguinis.They were followed-up for 6 months to 4 year and 3 months，7 was alive and well，2 of recrudescence or transfusion，4 died and 5 lost follow-up.They were cysti-solid lump or solid lump.T