abacavir阿巴卡韦.pptVIP

Abacavir Ababavir is a selective reverse transcriptase inhibitor for the treatment of human HIV and hepatitis B viruses . 第1页/共9页 Abacavir 第2页/共9页 The intermediates for Abacavir γ-lactam 2-azabicyclo hept-5-en-3-one is the intermediates for Abacavir. 第3页/共9页 Enzymatic preparation of 1 Synthetic route plan： A biocatalytic process was developed for the resolution of racemic γ-lactam 2 to yield the desired 1 and amino acid 3. 第4页/共9页 γ-lactamase containing organisms : 1. Pseudomonas solonacearum NCIMB 40249 2. Rhodococcus NCIMB40213. But the enzymatic process need lactamase