CLINICAL CHEMISTRY CHAPTER 22课件.pptVIP

CLINICAL CHEMISTRYCHAPTER 22 LIVER FUNCTION Introduction OK, so your beautiful new baby is a little “yellow.” And why did the doctor put your baby in a “tanning” booth? You told your family the baby was a little “jaundiced.” But what does that mean? Merriam-Webster Dictionary 2 : exhibiting or influenced by envy, distaste, or hostility a jaundiced eye Does that mean your beautiful new baby is going to grow up to be evil? Good news!! Your baby is probably not the anti-Christ and he/she is also probably totally normal and healthy Say tuned to find out why!!! Key Terms Bile Bilirubin Total bilirubin Conjugated / Unconjugated Bilirubin Free bilirubin Kupffer cells Cirrhosis Jaundice Icteric Gallstones Urobilinogen UDPG Albumin Prehepatic, hepatic, post hepatic diseases Gilbert’s Syndrome Crigler – Najjar Syndrome Dubin – Johnson Syndrome Kernicterus HDNB Cholestasis Physiologic Jaundice of the newborn Diazo reagent Accelerators Ehrlich Reaction Evelyn – Malloy Reaction Jendrassik – Grof Reaction Direct Bilirubin Measurement Reye’s Disease Reticuloendothelial ( RE ) System Objectives List some of the general functions of the liver involving bile production and secretion, synthesis of other substances and detoxification Discuss the origin and formation of bilirubin Discuss the common methodologies and principles that are use to determine bilirubin concentrations Classify the three general types of jaundice and list causes for each Interpret laboratory bilirubin test results and identify possible disease conditions Discuss proper collection and processing of bilirubin specimens Meet you liver !!! The liver is responsible for many important metabolic functions 100 lab tests associated with liver function Liver is connected to the circulatory system by Hepatic artery : Provides it’s blood supply Portal vein : Transports absorbed substances from the GI tract Lobules are the functional units, consisting of clusters of hepato