benezen课件.pptVIP

You must master What is the main route of absorption of benzene in workplace? What is the main storage tissue of benzene in the body? What is the effect system of acute benzene poisoning? (central nervous system) What is the effect system of chronic benzene poisoning? (hematopoietic system), what are the first blood cells benzene affect? Benzene, also known as benzol, is a colorless liquid with a sweet odor. The history of use and poisoning After benzene was found in 19th century, it came into industrial use as a solvent in the printing, paint and other chemical industries. At the same time, its toxicity on blood formation have been recognized. The history of use and poisoning The history of use and poisoning In 1909, in Maryland (the United States), three girls that had been exposed to benzene for a period of 4-5 months died within 1 month. The benzene exposure came from vapors of benzene that was used as a rubber solvent in sealing tin cans. The history of poisoning This expansion in the industrial uses of benzene was accompanied by a vast increase in the numbers of benzene poisoning. The history of poisoning The history of poisoning Benzene exposure is strongly associated with leukemia. In 1982, the International Agency for Research on Cancer (IARC) concluded that there is sufficient evidence that benzene is carcinogenic to human. IARC classified benzene as a group 1 carcinogen (Carcinogenic to humans) – leukemia Here we will find benzene Environmental and living exposure The main metabolism product is phenol. It can combine to sulphates and glucuronides, and excrete with urine Toxicology Mechanisms (2) Chronic Toxicity In chronic exposures, benzene metabolites are considered the toxic agents, not the parent compound. Chronic poisoning Benzene can do harm to hematopoietic system, disrupt normal blood production and cause a decrease in important blood components. Chronic Benzene Toxicity Benzene is a known carcinogen.