icslaba与单独ics治疗儿童中重度哮喘系统评价-systematic review of ic slaba and ics alone in the treatment of moderate to severe asthma in children.docx

新疆医科大学医学硕士学位论文-0.33,95%CI(-0.37,-0.29) ; combined group had a statistical difference on reducing the days of using rescue drugs with WMD -1.38,95%CI(-2.33,-0.43);(6)decrease the number of exacerbations: one study reports emergency department visits and hospitalizations. compared with controlled group, combined group had a statistical difference on decreasing the number of ED visits with WMD -1.36,95%CI(-1.49,-1.23) and had a statistical difference on decreasing the number of hospitalizations with WMD -0.34,95%CI(-0.40,-0.28); Conclusions：The limited evidences proved that in facets of improving PEFvalue in the subgroup of constant drug dose and improving PEF%、decreasing clinical symptoms in the day and reducing clinical symptoms in the night in the subgroup of same drug dose for different desease degree and decreasing the using of rescue drugs and decreasing the number of exacerbations , ICS/LABA is better than ICS alone. But in the facets of reducing clinical symptoms in the night in the subgroup of different drug dose for different desease degree and improving PEF value in the subgroup of non-constant drug dose, ICS/LABA is worse than ICS alone; But in the facets of improving clinical efficiency and decreasing clinical symptoms in the day and night and reducing adverseevents, there is not positive result, a lot of well-designed RCTs are needed for verifying results.Key Word：moderate and severe asthma of children；inhaled corticosteroid/long actingβ2 agonist,；systematic review,；random controlled trials(RCT)—4—中英文缩略词对照表英文缩写英文全名中文译名ICSInhaled corticosteroid吸入糖皮质激素LABALong acting beta2antagonist长效受体激动剂PEFPeak expiratory flow呼气峰流速学位论文独创性说明本人所呈交的学位论文是在我导师的指导下进行的研究工作及取得的成果。 据我所知，除文中已经注明引用的内容外，本论文不包含其他个人已经发表或撰 写过的研究成果。对本文的研究作出重要贡献的个人和集体，均已在文中作了明 确的说明并表示谢意。研究生签名：时间：年月日学位论文版权授权书本人完全了解新疆医科大学有关保留、使用学位论文的规定，学校有权保 留学位论文并向国家主管部门或指定机构送交论文的电子版和纸质版。有权将学 位论文用于赢利目的的少量复制并允许论文进入学校图书馆被查询。有权将学位 论文的内容编入有关数据进行检索，有权将学位论文的标题和摘要汇编出版。保 密的学位论文在解密后使用本规定。研究生签名：时间：年月日导师签名：时间：年月日前 言前言支气管哮喘(简