il6 il8 nfκb vegf在翼状胬肉中表达的研究-expression of il6 il8 nf κ b vegf in pterygium.docx

目录中文摘要·········································································································1英文摘要········································································································4英文缩写·········································································································8研究论文IL-6、IL-8、NF-κB、VEGF在翼状胬肉中表达的研究前言·········································································································9材料与方法····························································································10结果········································································································14附图········································································································15附表········································································································16讨论·······································································································17结论·······································································································21参考文献································································································22综述翼状胬肉发病机制的研究进展····························································24致谢··········································································································37个人简历········································································································38IL-6、IL-8、NF-κB、VEGF在翼状胬肉中表达的研究摘要目的：翼状胬肉（pterygium）是局部的球结膜纤维血管组织异常增生以致侵入角膜表面的一种疾病，是临床上最常见的眼表疾病之一，可单眼或者双眼同时发病。翼状胬肉的发病机制十分复杂，可能是由某一个主要致病因素引起的，同时也可能是多个相关致病因素共同作用的结果，至今尚无定论。目前认为过量的紫外线辐射是导致翼状胬肉发病的高危因素。翼状胬肉患者可由于角膜的形态的改变而引起不规则散光，从而可不同程度地影响患者的视力。目前翼状胬肉切除术被认为是最有效的治疗方法，但是翼状胬肉切除术后再次复发的手术并发症仍然不能避免。为了解决这个难题，我们必须更加深入的探讨翼状胬肉的发病机制，以期从根本上解决翼状胬肉复发的手术并发症。近年来，关于翼状胬肉发病机制的实验研究很多，其中大多数重点集中在对紫外线照射、细胞因子的异常表达、细胞的异常凋亡以及增殖等在翼状胬肉发病中的重要作用的研究。近期有研究表明，翼状胬肉的发病机制与炎症因子的表达密切相关，本实验着重从炎症因子以及血管内皮生长因子、核转录因子等表达方面来说明翼状胬肉的发生与发展