il17 il22在贲门失弛缓症患者血清及食管下括约肌中的表达及意义-expression and significance of il17 il22 in serum and lower esophageal sphincter of patients with achalasia.docx

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il17 il22在贲门失弛缓症患者血清及食管下括约肌中的表达及意义-expression and significance of il17 il22 in serum and lower esophageal sphincter of patients with achalasia.docx

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il17 il22在贲门失弛缓症患者血清及食管下括约肌中的表达及意义-expression and significance of il17 il22 in serum and lower esophageal sphincter of patients with achalasia

目录中文摘要············································································································1 英文摘要············································································································4 英文缩写············································································································8 研究论文 IL-17、IL-22 在贲门失弛缓症患者血清及食管下括约肌中的表达及意义前言············································································································9 材料与方法······························································································10 结果··········································································································15 附图··········································································································16 附表··········································································································21 讨论··········································································································22 结论··········································································································28 参考文献··································································································29综述贲门失弛缓症的发病机制及病因学研究进展····································34 致谢··················································································································48 个人简历··········································································································49IL-17、IL-22 在贲门失弛缓症患者血清及食管下括约肌中的表达及意义摘要贲门失弛缓症（Achalasia, AC）是一种因食管蠕动减弱或消失、食管下括约肌（Lower esophageal sphincter, LES）松弛障碍而导致的食管动力性疾病。该疾病的病因及发病机制至今仍未完全阐明。目前有一种假说认为，AC 是多因素介导产生的疾病，即感染引起了 LES 肌间神经丛的炎症，随后该炎症激发有基因易感性的人产生了自身免疫反应，进而 LES 抑制性神经节遭到自身免疫介导的炎症破坏，受抑制性神经节支配的 LES 出现松弛障碍而形成 AC。因此，自身免疫介导的炎症反应可能在 AC 的发病过程中发挥着重要作用。白介素 17（Interleukin-17, IL-17）被认为是炎症性自身免疫疾病的关键介质，它能够促进中性粒细胞的聚集、固有免疫细胞的活化，并能够增强 B 细胞的功能以及诱导炎症因子的释放。白介素 22（Interleukin-22, IL-22）属于