老年功能性便秘的中医辨证分型及与焦虑 抑郁的相关性研究-study on tcm syndrome differentiation of senile functional constipation and its correlation with anxiety and depression.docxVIP
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老年功能性便秘的中医辨证分型及与焦虑 抑郁的相关性研究-study on tcm syndrome differentiation of senile functional constipation and its correlation with anxiety and depression
中文摘要目的:通过分析年龄、性别、便秘的严重程度、中医证型分布及其与焦虑、抑郁的关系,为老年功能性便秘的辨证论治提供一定的帮助,为进一步研究中医证型与焦虑、抑郁等心理障碍的关系提供一定的理论基础和临床依据。方法:临床随机抽取年龄大于60岁功能性便秘患者150例,60岁以上健康老年人50例作为对照组,且都符合入组标准,所有受试者均知情同意,对所有受试者进行现场HAMA、HAMD及便秘评分,对FC患者按中医诊断标准进行辨证分型,所有数据均用SPSS19.0统计分析软件进行分析。结果:(1)老年功能性便秘组的的焦虑及抑郁的倾向、程度都明显高于健康对照组。其中便秘组有焦虑、抑郁倾向的高达77.33%和62.67%,健康对照组仅仅18%和12%。(2)中医证型分布按频次从高到低依次为:脾胃气虚证、阴虚肠燥证、气机郁滞证、脾肾阳虚证、肠胃积热证,男女证型分布无显著差异(P=0.586)。(3)各中医证型中,气机郁滞证患者的HAMA及HAMD得分均明显高于其他各证型,其中HAMA得分与脾胃气虚证、阴虚肠燥证有显著差异(P值分别为:0.000、0.029),HAMD得分与脾胃气虚证、阴虚肠燥证、脾肾阳虚证有显著差异(P值分别为0.001、0.000、0.026)。(4)便秘组男女比例为1:1.83,1女性便秘患者的HAMA和HAMD得分均略高于男性,但无统计学意义(P值分别为0.469、0.578)。(5)老年功能性便秘患者的HAMA及HAMD得分与Wexner便秘评分、便秘病史(年)、每次排便时间(分钟)、每24小时排便失败次数均呈正相关,与每周排便次数呈负相关,其中与便秘评分及便秘病史相关性最强。结论:老年功能性便秘患者的焦虑、抑郁的倾向及程度均明显高于健康对照组;临床上,老年功能性便秘以虚秘为主,其中证型以脾胃气虚证和阴虚肠燥证为主,且男女证型分布无显著差异;其中,气机郁滞与焦虑、抑郁关系尤为密切。女性较男性更易发生便秘,但便秘与焦虑、抑郁无显著的相关性;老年功能性便秘患者的焦虑、抑郁的倾向及程度与便秘的病史长短及严重程度呈明显的正相关。关键词:老年性,功能性便秘,证型分布,焦虑,抑郁,汉密尔顿焦虑量表(HAMA),汉密尔顿抑郁量表(HAMD)2AbstractObjective:throughtheanalysisofage,gender,severityofconstipation,TCMsyndrometypedistributionandanxiety,depression,treatmentprovidescertainhelpforthedifferentiationofSenileFunctionalconstipationontherelationship,forthefurtherstudyofTCMsyndromeandanxiety,depressionandotherpsychologicaldisordersandprovidecertaintheoreticalbasisandclinicalevidence.Methods:theclinicalrandomagemorethan60yearsinpatientswithfunctionalconstipationin150patients,60healthyoldpeopleand50casesascontrolgroup,andthegroupmeetsthestandards,informedconsentwasobtainedfromallsubjects,siteHAMA,HAMDandconstipationscoreonallsubjects,inpatientswithFCsyndromedifferentiationinTCMdiagnosticcriteriaofclassification,allthedatawerestatisticallyanalyzedbySPSS19softwareanalysis.Results:(1)Theconstipationgroupofanxiety,depressionandweresignificantlyhigherthanthatofthecontrolgroup.Upto77.33%and62.67%ofwhichhavethetendencytodepressionanxiety,constipationgroup,healthycontrolgroupjust18%and12%.(2)TheTCMsyndromedistributionaccordingtothefrequencyfromhightolow:spleenstomachqideficiency,yindeficiency
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