2015基层糖尿病指南培训.pptVIP

2型糖尿病患者给予安慰剂时，血浆葡萄糖、胰岛素和胰高糖素的浓度几乎没有变化。如果给予GLP－1静脉注射，胰岛素的分泌明显增加，胰高糖素的分泌则显著减少，从而带来血浆葡萄糖浓度的下降。但是，当血糖接近正常水平时，GLP－1对胰岛素分泌的刺激作用即减弱，对胰高糖素分泌的抑制作用也减弱。从而避免低血糖的发生，达到精准控糖的目的。 Glucose-Dependent Effects of GLP-1 on Insulin and Glucagon Levels in Patients With Type 2 Diabetes This slide shows results from a study that characterized changes in glucose, insulin, and glucagon levels in response to a pharmacologic infusion of GLP-1. Ten patients with uncontrolled type 2 diabetes mellitus being treated with diet and oral hypoglycemic agents received an intravenous infusion of GLP-1 over 240 minutes. During infu