NF1 Tumor Suppressor Gene：NF1肿瘤抑制基因.pptVIP

NF1: Tumor Suppressor Gene Presentation by Hana Masood Overview of Presentation Disease – Neurofibromatosis Type I NF1 Gene Protein - Neurofibromin Protein Function – RasGAP Biological Role – Active in Ras Pathway NF1 gene and Neurofibromin Role in Cancer Neurofibromatosis Type I Among most common neurogenetic disorders -It is heritable; all affected members of family have same form of NF Affects 1 in 3,500 Whereas NF2 affects only 1 in 40,000 Diagnosis based on any 2 of the following clinical criteria: - Greater than or equal to 6 café-au-lait spots - Freckles? underarm or groin - Greater tha