芪参复康胶囊抗焦虑作用研究.docVIP

芪参复康胶囊抗焦虑作用研究 　　[摘要]目的：研究芪参复康胶囊的抗焦虑作用。方法：给小鼠灌胃芪参复康胶囊内容物，剂量为0.6、1.2 g/kg；以地西泮(diazepam) 0.005 g/kg、丁螺环酮(buspirone) 0.001 g/kg灌胃，作阳性对照；并以生理盐水设空白对照组。连续给药14 d，然后分别对小鼠进行双向主动回避试验、明暗穿箱试验和高架十字迷宫试验。结果：芪参复康胶囊组可减少小鼠的非条件反应次数及试验间的错误动作次数，减少小鼠在暗室的滞留时间，增强小鼠对白室的探究兴趣，增加在白室的滞留时间，明显增加小鼠进入高架十字迷宫开臂的次数。三种试验结果表明，芪参复康胶囊2个剂量组与2个阳性对照组比较，各项指标无显著性差异（P0.05）。结论：芪参复康胶囊具有很好的抗焦虑作用。 　　[关键词]芪参复康胶囊；小鼠；抗焦虑 　　[中图分类号]R964 [文献标识码]B[文章编号]1673-7210（2007）11（a）-092-02 　　 　　The research on the anxiolytic effect of Qishen Fukang Capsules 　　LIN Yu,LI Xin-tian,SHI Feng-qing,QIU Cai-rong,YANG Lai-qi ,YANG Jun-ling 　　( Department Pharmcy of the 3rd Hospital of PLA, BaoJi 721004,China) 　　[Abstract]Objective: To study the anxiolytic effect of Qishen Fukang Capsules. Methods: Qishen Fukang Capsules were given to the mice ig with the dosage of 0.6,1.2 g/kg. For the positive control, diazepam was given to the mice ig with the dosage of 0.005 g/kg and buspirone 0.001 g/kg. Blank control group was set up with NS.After administration of 14 consecutive days, two-way active avoidance experiments, shading wear box test and elevated maze test were carried on the mice. Results: Qishen Fukang Capsules group could reduce the numbers of non-response to the conditions and the numbers of wrong moves, could reduce the retention time in the darkroom,could increase the explore interest in the bright room，the stay time in bright room and significantly the numbers of opening arms entering the EPM. Three experimental results showed that the indicators between Qishen Fukang Capsules group and the two positive control groups were no significant difference (P0.05). Conclusion: Qishen Fukang Capsules have a good anxiolytic effect. 　　[Key words]Qishen Fukang Capsules; Mice; Anxiolytic effect 　　 　　随着生活节奏的加快，焦虑、烦躁、沮丧和紧张等不良情绪正在困扰着越来越多的人。如果长期处于精神紧张状态，将使自身免疫力降低，导致焦虑症的发生。中医理论认为，心气不足则烦躁而不安。结合该病现代预防和治疗的经验，本研究选用我院临床用于治疗焦虑症的验方并对其加以增益优化，研制出了芪参复康胶囊，该药由西洋参、黄芪、天麻等组成。为了对该制剂的临床应用提供依据，我们就其对小鼠的抗焦虑作用进行了研究，现报道如下： 　　 　　1 实验材料 　　 　　1.1 动物 　　昆明种小鼠，雄性