利培酮与舒必利对精神分裂症患者血脂代谢影响.docVIP

利培酮与舒必利对精神分裂症患者血脂代谢影响 　　[摘要] 目的：探讨利培酮和舒必利对首发精神分裂症患者血脂代谢的影响。方法：对2008年1月~2010年1月我院住院的精神分裂症患者547例测定利培酮和舒必利治疗8周前后的血胆固醇（TC）及三酰甘油（TG）浓度。结果：①利培酮治疗后，血胆固醇及血三酰甘油明显升高（t=2.94，P=0.003；t=2.56，P=0.011），且男性患者组升高较女性明显（t=2.47，P=0.015；t=2.29，P=0.023）；②舒必利组治疗后血胆固醇及血三酰甘油明显升高（t=2.35，P=0.019；t=2.16，P=0.032），且女性TG升高的程度显著大于男性患者（t=3.11，P=0.002）。③利培酮对于血胆固醇及三酰甘油的影响大于舒必利（t=3.24，P=0.001；t=2.27，P=0.021）。结论：利培酮使血胆固醇及三酰甘油水平升高，对男性影响大。舒必利使血胆固醇及三酰甘油水平升高，对女性影响大。利培酮对TC的影响大于舒必利。 　　[关键词] 利培酮；舒必利；精??分裂症；血脂 　　[中图分类号] R971.4 [文献标识码] A [文章编号] 1673-7210（2011）07（a）-015-03 　　 　　The side-effects of Risperidone and Sulpiride on the lipid metabolism in the schizophrenic patients 　　HUANG Jianping1, CUI Donghong2, ZHANG Chen2, WANG Zucheng2, SU Yousong2* 　　1.Mental Health Center of Minhang District in Shanghai City, Shanghai 201100, China; 2.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China 　　[Abstract] Objective: To explore the side-effects of Risperidone and Sulpiride on the lipid metabolism in schizophrenic patients. Methods: 547 schizophrenic inpatients were recruited from January 2008 to January 2010. The concentrations of TC and TG after 8 week Risperidone or Sulpiride treatment were detected. Results: ①After Risperidone treatment, TC and TG concentrations were significantly increased (t=2.94, P=0.003; t=2.56, P=0.011). Moreover, male patients had the more severe side-effects on the lipid metabolism than female (t=2.47, P=0.015; t=2.29, P=0.023). ②After Sulpiride treatment, TC and TG concentrations were significantly increased (t=2.35, P=0.019; t=2.16, P=0.032). Moreover, TG concentrations of female patients increased more highly than those of male (t=3.11, P=0.002). ③Risperidone had the more effects on TC and TG than Sulpiride (t=3.24, P=0.001; t=2.27, P=0.021). Conclusion: Risperidone could raise the TC and TG concentrations, and more greatly in male patients. Sulpiride raises the TC and TG concentrations, and more greatly in female patients. Risp