奥沙利铂联合卡培他滨治疗胃癌临床疗效观察.docVIP

奥沙利铂联合卡培他滨治疗胃癌临床疗效观察 　　【摘要】探讨：奥沙顺铂联合卡培他滨用于治疗晚期胃癌的疗效以及安全性。方法：选取我院44例胃癌患者为研究对象，随机分为A、B两组。其中A组给予奥沙利铂静脉滴注2h（130mg/m3），卡培他滨2g/m2，连用14d，每3w为1个疗程，共2疗程。B组第一天给予奥沙利铂（剂量85mg/m2），同时在第1天和第2天给予甲酰四氢叶酸钙（200mg/m2）以及氟尿嘧啶（400mg/m2）静脉滴注，随后持续泵入氟尿嘧啶（600mg/m2）22h。2周为1个疗程，4个疗程后对效果进行评价。结果2组总体有效率为47.7%，其中A组总体有效率为54.5%，中间疾病进展时间为25w，B组整体有效率为40.1%，中位疾病进展时间为23w，两组差异无统计学意义。患者不良反应轻微，主要为消化道以及骨髓抑制。结论：奥沙顺铂联合卡培他滨治疗晚期胃癌，患者具有较好的反应性和耐受性。 　　【关键词】用奥沙利铂；卡培他滨；胃癌 　　Clinical observation of therapeutic effect of Oxaliplatin plus Capecitabine in the Treatment of Gastric Cancer 　　【Abstract】ObjectiveTo evaluate the efficacy and safety of oxaliplatin plus Capecitabine in the treatment of gastric cancer. Methods44 patients diagnosed as gastric cancer were randomly assigned to receive the regimen of Oxaliplatin plus Capecitabine (n=22, group A) or oxaliplatin plus 5-fluorouracil/Calcium folinate (n=22, group B). Group A consisting of oxaliplatin (130 mg/m2) on day 1, Capecitabine 2g/m2, bid, with the first dose on the evening of day 1 and the last dose on the morning of day 15, repeated every 3 weeks. Group B consisting of oxaliplatin (85 mg/m2) on day 1, Calcium folinate (200 mg/m2) infusion in 2 hours followed by bolus 5-fluorouracil (400 mg/m2 ) and a 22h duration of 5-fluorouracil (600 mg/m2), repeated for 2 consecutive days every 2 weeks. ResultsThe overall response rate was 47.7%. The response rate was 54.5% for group A and 40.1% for group B. The median time to progression in group A and group B was 25 weeks and 23 weeks, respectively. The most common adverse reactions were gastrointestinal reaction and marrow suppression. ConclusionThe regimen of Capecitabine plus oxaliplatinis effective for treating gastric cancer with tolerable adverse effects. 　　【Key words】 Oxaliplatin; Capecitabine; Gastric Cancer 　　【中图分类号】R436【文献标识码】B【文章编号】1005-0515(2011)04-0326-02 　　 　　胃癌是消化系统最常见的恶性肿瘤之一，在我国，每年有近30万人死于此病[1]。尽管根治性手术是治疗非转移性胃癌的主要方法，但胃癌依然具有较高的复发率，因此，化疗依然是治疗胃癌的重要方法[2]。在本研究当中，我们采用奥沙利铂联合卡培他滨治疗胃癌22例，临床研究结果如下。 　　1 资料和方法