Lecture 6, Midterm_Review STATISTICAL ISSUES IN THE DESIGN AND ANALYSIS OF CLINICAL STUDIES 生物统计课件教学讲义.pptxVIP

STATISTICAL ISSUES IN THE DESIGN AND ANALYSIS OF CLINICAL STUDIES;Designing a Clinical Research Study;Example 1: The Monitored Atherosclerosis Regression Study (MARS);Designing a Clinical Research Study;Types of Clinical Research Designs;Examples (continued);Designing a Clinical Research Study;Types of Study Variables;Types of Study Variables;Types of Study Variables (continued);Types of Study Variables (continued);Rationale for Identifying the Type of Outcome Measure;Examples (continued);Designing a Clinical Research Study;Types of Hypotheses;Example 1: MARS;Designing a Clinical Research Study;Modes of Acquisition of Sample;Examples (continued);Selection of Numbers of Subjects;Example: MARS and power calculation;Example: MARS and nQuery;Designing a Clinical Research Study;Procedures for Testing Statistical Hypotheses;Procedures for Testing Statistical Hypotheses (cont’d);Analytic Methods for Discrete Dichotomous Outcome Variables;Example 1a: MARS;Example 1a: MARS;Example 1a: MARS;Hb. Analytic Methods for Continuous or Discrete/Multicategorial Outcome Variables;Example 1b: MARS;Example 1b: MARS;Example 1b: MARS;Example 1c: MARS;Example 1c: MARS;Example 1c: MARS;Hc. Paired vs. Two-Sample Combo;Example 1d: MARS;Final Recommendations for Conducting Clinical Research;;Open book, open notes ~2 hours 40% final score No electronics except a calculator is allowed. Zero tolerance for cheating