西乐葆治疗骨关节炎上消化道安全性.pptVIP

09/25/09 * 研究设计 一项单剂量、双中心、随机双盲、活性药物与安慰剂对照研究 评估与比较口腔科术后塞来昔布400 mg 、布洛芬400 mg 或安慰剂的疗效与安全性 纳入人群 健康志愿者，年龄 18岁；需要接受至少2颗第3磨牙拔除术； 视觉模拟评分(VAS) 50 mm (0-100mm) 塞来昔布 400 mg (n=57) ，布洛芬 400 mg (n=57)，安慰剂 (n=57) 疗效评估 镇痛药物起效时间 疼痛强度差别 (PID) 疼痛缓解 (PR) 09/25/09 * * 09/25/09 * 研究设计 一项单剂量、双中心、随机双盲、活性药物与安慰剂对照研究 评估与比较口腔科术后塞来昔布400 mg 、布洛芬400 mg 或安慰剂的疗效与安全性 纳入人群 健康志愿者，年龄 18岁；需要接受至少2颗第3磨牙拔除术； 视觉模拟评分(VAS) 50 mm (0-100mm) 塞来昔布 400 mg (n=57) ，布洛芬 400 mg (n=57)，安慰剂 (n=57) 疗效评估 镇痛药物起效时间 疼痛强度差别 (PID) 疼痛缓解 (PR) 09/25/09 * Key point: Celecoxib is as effective as common ns-NSAIDs in the management of acute pain. Background: Results from numerous randomized clinical trials demonstrate the efficacy of celecoxib in the management of various acute pain models: An ankle sprain trial by Ekman et al. showed faster recovery with celecoxib vs. ibuprofen, shown by a higher rate of moderate or complete recovery by day 4. In addition, patients returned to function, on average, 1 day sooner with celecoxib vs. ibuprofen. An ankle sprain trial conducted by Petrella et al. demonstrated efficacy with celecoxib is equivalent to that of naproxen. Celecoxib treatment resulted in sustained pain relief across all efficacy and function measures. A randomized trial in patients with shoulder tendinitis demonstrated improved pain relief with celecoxib vs. naproxen. Celecoxib significantly improved maximum pain intensity scores through day 14, while naproxen was not statistically significantly different from placebo at day 14. In addition, improved function was noted as early as day 3 with celecoxib, 1 day earlier than naproxen. An acute low back pain trial demonstrated that celecoxib provides efficacy comparable with that of the maximum recommended dose of diclofenac. In summary, celecoxib is consistently as effective as nonselective NSAIDs, including diclofenac, naproxen, and ibuprofen in the treatment of acute pain. References: Ekman EF et al. Efficacy of celecoxib versus ibuprofen in the treatment of acut