从动脉粥样硬化形成机制看调脂治疗策略- 精品.pptVIP

调整为降低每单位LDL-C 降低 LDL-C ORCHD(95% CI) RRR(95% CI) 1.0mmol/L (38.7mg/dl) 0.46(0.41-0.52) 54%(48-59) 0.5mmol/L (19.3mg/dl) 0.68(0.64-0.71) 32%(29-36) 0.25mmol/L (9.7mg/dl) 0.82(0.80-0.85) 18%(15-20) 0.125mmol/L (4.8mg/dl) 0.91(0.90-0.92) 9%(8-10) Mega-mRCT N=312.321（多种 SNPs 的非重叠数据） 0.4 0.5 0.6 0.7 0.8 0.9 1.0 *SNPs prioritized for inclusion in mega-mRCT by inverse variance of summary OR adjusted per unit lower LDL-C *Objective: More precisely quantity the effect of lifelong exposure to each unit lower LDL-C on risk of CHD J Am Coll Cardiol 2012;60:2631–9 Proportional reduction in event rate (SE)