肝脏tcrγδcd3cd4-cd8-t细胞在小鼠病毒性肝炎中的作用及其作用机制-role and mechanism of liver tcr γ δ cd3cd4 - cd8 - t cells in mouse viral hepatitis.docxVIP

综述：CD3+CD4-CD8-双阴性 T 细胞的研究进展 64附录 1：攻读博士学位期间已发表和拟发表论文··························································· 75 附录 2：英文缩略语对照表······························································································· 77 致 谢 ·································································································································· 79肝脏TCRγδ+ CD3+ CD4- CD8- T 细胞在小鼠病毒性肝炎中的作 用及其作用机制博士研究生：陆玉蕾 指导老师： 宁琴教授华中科技大学同济医学院附属同济医院感染科 华中科技大学同济医学院附属同济医院感染性疾病研究所中文摘要【研究背景及目的】 病毒性肝炎以肝细胞损伤为主要特征，然而肝细胞损伤的具体机制尚未完全明确。目前大部分学者认为肝炎病毒本身并不直接造成肝细胞的损伤，而机体抗肝炎病 毒的免疫反应，特别是免疫细胞介导的免疫反应，是造成肝细胞损伤的主要