植物甾醇对高血脂大鼠血脂水平的影响.pdfVIP

306 2011, Vol. 32, No. 11 食品科学 ※营养卫生 张泽生， 侯冬梅 * ，贺 伟，王婧宜 (天津科技大学食品工程与生物技术学院，天津 300457) 目的：通过体内给药动物实验探讨植物甾醇的降血脂功效。方法：将雄性SD 大鼠随机分为 5 组，分别 饲喂基础饲料(正常组) 、高脂饲料(模型组)和添加质量分数为 0.5% 、1.0%、2.0% 植物甾醇的高脂饲料(剂量组) ， 检测相关指标。结果：饲喂高脂饲料的干预组总胆固醇(TC) 、甘油三酯(TG)和非高密度脂蛋白胆固醇(non-HDL-C) 水平较模型组显著降低(P ＜0.01) ，高密度脂蛋白胆固醇(HDL-C)水平显著升高(P ＜0.01) ，且随着植物甾醇添加量 的增加呈现一定的剂量效应。模型组胆碱酯酶(CHE)活力在血清及肝脏中显著降低(P ＜0.01) ，剂量组CHE 活力随 着植物甾醇剂量的增加而升高。结论：植物甾醇对高血脂症大鼠血脂水平具有显著降低作用，并且具有抑制脂质 过氧化和保护肝脏的作用。 植物甾醇；高血脂；大鼠；胆碱酯酶 Effect of Phytosterol on Blood Lipid in Hyperlipidemia Rats ZHANG Ze-sheng ，HOU Dong-mei* ，HE Wei ，WANG Jing-yi ( College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China) Abstract ：Objective: To explore the effect of phytosterol on lowering blood lipid in vivo. Methods: The experimental animals were divided into 5 groups including the control group fed with a basal diet, model group given with a high-fat diet and three intervention groups administered with phytosterol at does of 0.5%, 1.0% and 2.0%. Hyperlipidemic indicators were tested. Results: Total cholesterol (TC), triglyceride(TG) and non-high density lipoprotein cholesterol (non-HDL-C) exhibited a signifi- cant decrease and high density lipoprotein cholesterol (HDL-C) revealed an obvious increase in a dose-dependent manner in rats from the intervention groups. However, the model group exhibited opposite results. The activity of cholinesterase (CHE) was decreased in plasma and liver in the model group, but the CHE activity in the intervention groups was improved. Conclusion: Phytosterol has obvious effect on lowering blood lipid and inhibiting lipid peroxidation, thereby having hepatoprotective effect. Key words ：phytosterol ；