建立基因敲除小鼠颈动脉粥样硬化模型（英文）课件.pptVIP

Lipoprotein Lipase (LPL) Deficiency Increases Plasma Lipid Level and Enhances Neointima Formation After Carotid Artery Injury in apoE Knock-out Mice Candidate genes in lipoprotein metabolism Lipoprotein Lipase in the Arterial Wall Lipoprotein Lipase in the Arterial Wall Hypothesis neointima formation after carotid artery injury by FeCl3 for 8 weeks neointima formation after carotid artery injury by FeCl3 for 8 weeks Mean Intimal and Medial Cross-sectional Areas of EK and ELK Mice 8 Weeks after Injury lipid deposit after carotid artery injury by FeCl3 for 8 weeks lipid deposit after carotid artery injury by FeCl3 for 8 weeks lipid deposit after carotid artery injury by FeCl3 for 8 weeks lipid deposit after carotid artery injury by FeCl3 for 8 weeks Reference Mary Beth DeYoung, Clifford Tom, David A. Dichek, et al Plasminogen Activator Inhibitor Type 1 Increases Neointima Formation in Balloon-Injured Rat Carotid Arteries. Circulation. 2001;104:1972-1977 Koichi Kaikita, Agnes B. Fogo, Lijun Ma, John A. Schoenhard, Nancy J. Brown, Douglas E. Vaughan, et al Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long-term Nitric Oxide Synthase Inhibition. Circulation. 2001;104:839-844 Yanhong Zhu, Peter M. Farrehi, William P. Fay, et al Plasminogen Activator Inhibitor Type 1 Enhances Neointima Formation After Oxidative Vascular Injury in Atherosclerosis-Prone Mice. Circulation. 2001;103:3105-3110 Marianne Pynn, Katrin Sch?fer, Stavros Konstantinides, Martin Halle, et al Exercise Training Reduces Neointimal Growth and Stabilizes Vascular Lesions Developing After Injury in Apolipoprotein E–Deficient Mice Circulation. 2004;109:386-392 Future Works * Lusis et al Circulation. 2004 Pentik?inen et al Arterioscler Thromb Vasc Biol. 2002 Pentik?inen et al Arterioscler Thromb Vasc Biol. 2002 LPL Arterial response to injury hyperlipidemic conditions ？ A 1x2-mm strip of filter paper saturated with