rhepo对宫内炎症致新生大鼠脑白质损伤脑组织nmda r1mrna及epor表达水平的影响-effect of rhe po on nmda r1 mrna and epor expression in white matter injured brain tissue of neonatal rats induced by intrauterine inflammation.docxVIP

结论1.孕鼠腹腔内注射LPS可成功模拟宫内感染模型，并导致新生鼠出现脑白质损伤。2.宫内炎症致脑白质损伤新生大鼠脑组织的NMDA过度活化，给予rhEPO治疗可抑制NMDA过度活化介导的氨基酸兴奋性毒性作用，促使EPOR表达上调，以减少宫内炎症致脑组织损伤,发挥神经保护作用。3.rhEPO治疗宫内感染致脑损伤应早期治疗，且14天的疗程目前为最佳疗程。硕士研究生吕欣（儿科学）指导教师姜红教授关键词：新生鼠；宫内感染；脑白质损伤；促红细胞生成素；促红细胞生成素受体；N-甲基-D-天门冬氨酸；AbstractObjective:Toexploretheneuroprotectiveeffectandcoursetreatmentofrecombinanthumanerythropoietin(rhEPO)onneonatalratswithwhitematterdamage(WMD)afterintrauterineinfectionMethods:12wistarratsat15daysofgestationwererandomlydividedintotwogroups:LPSgroup(n=9)andnon-infectiongroup(n=3).Theinfectiongroupwasestablishedanimalmodelofintrauterineinfectionbyin