rhoarho激酶信号通路对小鼠klotho蛋白表达的影响及替米沙坦的干预作用-effect of rhoarho kinase signal pathway on klotho protein expression in mice and telmisartan intervention.docxVIP

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2018-06-01 发布于上海
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rhoarho激酶信号通路对小鼠klotho蛋白表达的影响及替米沙坦的干预作用-effect of rhoarho kinase signal pathway on klotho protein expression in mice and telmisartan intervention.docx

rhoarho激酶信号通路对小鼠klotho蛋白表达的影响及替米沙坦的干预作用-effect of rhoarho kinase signal pathway on klotho protein expression in mice and telmisartan intervention

Conclusions:TheseresultssuggestthatL-NAMEcouldinduceddownregulationofexpressionKLproteinviaactivatedRhoA/Rho-kinasepathwayinmicebrain.[Keywords]RhoA/Rho-kinase;mice;Klothoprotein;fasudilPart2TheEffectandMechanismsofTelmisartanontheexpressionofKlothoproteininthebrainofmiceObjective:ToinvestigatetheeffectandthemechanismsofTelmisartanontheexpressionofKlothoproteininthebrainchoroidplexusinmice.Methods:32malekunmingmiceweredividedrandomlyintofourgroups:thenormalcontrolgroup,NOSblockade(L-NAME)group,TelmisartangroupandL-NAMEplusTelmisartangroup，andwereadministeredbycorrespondingmedicinerespectively,

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rhoarho激酶信号通路对小鼠klotho蛋白表达的影响及替米沙坦的干预作用-effect of rhoarho kinase signal pathway on klotho protein expression in mice and telmisartan intervention.docxVIP