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※ Drugs used in inducing immunity suppression ※ Inducing immune tolerance Problems we are facing today Organ source is limited Over 70% of the patients can not get suitable bone marrow donor. Quality of donor organs Legislation Although there are difficulties , The patients should not give up hope. The method we excogitate 1.The patients accept chemotherapy or radiotherapy to destroy the tumor and unhealthy bone marrow 2.Collected stem cells from the peripheral blood of donor 3.Imitate a thymic microenvironment of embryo phase 4.Inject the stem cells from donor into the imitative thymus 5.the stem cells will develop a suitable TCR for the receptor body with the help of his/her own MHC molecule, and the body will have a new T lymphocyte system THANK YOU MHC   marrow transplantation MHC and Marrow Transplantation History Basic definition Principle and processes of MHC and marrow transplantation Problems we are facing today The method we excogitate HISTORY HISTORY The first transplantation is cornea transplantation，it has a history of 200 years。 1824,Reisinger firstly designed cornea transplantation surgery. Joseph Murry firstly transplanted kidney between two twins in 1954. 1968,the first bone marrow transplantation succeeded. Reisinger Up to now ,the number of transplantation for heart ,liver ,kidney has reached 500,000 all over the world. During 2006,over 9500 patients received marrow transplantation . Transplantation began from 1960s in China ,and it develops rapidly. Definition  MHC： A large cluster of linked genes located in some chromosome in human or other mammals relate to immune response and immune regulation. MHC molecule : A group of protein encoded by MHC playing an important role in human immunity ,they can be divided into two kinds ——MHC-Ⅰ，MHC-Ⅱ Bone marrow transplantation Treat the patients with leukemia or similar disease through replacing his/her bad bone ma