原发性高血压伴左室肥厚及其和动脉僵硬度关系-primary hypertension with left ventricular hypertrophy and its relationship with arterial stiffness.docxVIP

THERESEARCHOFLEFTVENTRICULARHYPERTROPHYANDITSASSOCIATIONWITHARTERIALSTIFFNESSINESSENTIALHYPERTENSIONABSTRACTOBJECTIVES:Toinvestigatetheprevalenceandriskfactorsofleftventricularhypertrophy(LVH)inessentialhypertension(EH).Toexploretheeffectsofdiabetesmellitus(DM)onleftventriculargeometryinEH.ToevaluatethearterialstiffnessinhypertensivepatientswithLVH.METHODS:1.Weenrolled3536EHpatientsfrom2000to2007.Retrospectivestudywasperformedbasedontheclinicalcharacteristicsandechocardiographicexaminations.2.Weassessedtheleftventriculargeometrybyleftventricularmassindex(LVMI)andrelativewallthickness(RWT)inEHwithDM.ToanalysetheeffectsofDMonLVgeometry.3.Thepulsewaveanalysis,c-fPWV,C1andC2,carotidultrasoundwererecordedinsomehypertensionswithorwithoutLVH.RESULTS:1.TheprevalenceandriskfactorsofLVHinEH.①TheprevalenceofLVHwas17.8%inEH.Withthelevelofbloodpressureincreased,theprevalenceofLVHprogressivelyincreasedrespectively,5.9%、37.0%、57.1%.②TheEHpatientswithLVHshowedhigherage,bodymassindex(BMI),overweight,smoking,thedurationofEH,systolicbloodpressure(SBP)anddiastolicbloodpressure(DBP),fastingbloodglucose(FBG),2hpostprandialbloodglucose(PBG)anduricacid(UA)ascomparedwiththosewithoutLVH.Inaddition,theprevalenceofDMandhyperuricemiawithLVHwasalsohigherthanthenon-LVH.③Afteradjustingconfoundingfactors,LVMIwaspositivelyrelatedtotheBMI,smoking,thedurationofEH,SBP,2hPBGandUA,butforlowdensitylipoproteincholesterol(LDL-C)wasnegative,respectively.④SBP,thedurationofEH,DM,smoking,hyperuricemiaandBMIwererelatedtoLVMIindependently.TheeffectsofDMonLVgeometryinEH.①TheprevalenceofDMinEHwas27.0%.Age,weight,BMI,overweightandobesity,thedurationofEH,SBP,FBG,fastinginsulin,triglyceride(TG)andUAinEHwithDMwerehigherthanthosewithoutDM,whilehighdensitylipoproteincholesterol(HDL-C)waslowerinEHwithDM.②ComparedwithEH,leftventriculardiameterdiastolic(LVDd),leftventricularseptumthickness(LVST),leftventricularposteriorwallthickness(PWT),LVMI,RWT,concentricremodeling(CCR),concentrichypertrophy(CCH)andecentrichypertrophy(ECH