孕期酒精暴露对子鼠视网膜发育影响的分析-analysis of the effect of alcohol exposure during pregnancy on the retinal development of offspring rats.docxVIP

Using immunocytochemical methods, models in the control group and alcohol group on P7, P14 and P30 mice of all ages scripts development of retinal bipolar cell morphology in general, the results showed alcohol compared with the control group model bipolar cells In its development process as a general morphological differences, such as reducing the number of cell bodies, axons by reducing the density decreases and so, in the high dose group, these differences of alcohol more pronounced, indicating that alcohol exposure during pregnancy affect the sub-retinal bipolar cell development, and adose-dependent effects and long-range effect.Alcohol exposure during pregnancy affect the development of sub-retinal horizontal cellUsing DiI scattering, in the control group and model group on P7, P14 and P30 each age level piece retinal cells were marked and observed the level of the general morphology of cell development, the results showed alcohol levels of exposed group than in the control group, cells in the developing there are obvious differences, such as reducing the number of dendrites, dendritic length longer short, horizontal cell receptive field decreases and so, especially in the high-dose alcohol group, these changes more evident, indicating that alcohol exposure during pregnancy affect the child retinal horizontal cells development, and a dose-dependent effects and long-range effect.In short, the retina and visual form in the visual transduction plays a very important role, through the study of this issue, so we further recognize that alcohol abuse during pregnancy on the offspring of the harm caused by alcohol exposure during pregnancy in particular, will affect the offspring of retinal development, and its influence on the offspring of the retina in a dose and long-range effect, which is explained as caused by exposure to alcohol during pregnancy-related eye diseases such as amblyopia, strabismus and other pathogenesis are of great significance, and this For prenat