FPN1基因多态性与HiHiLo训练后血象指标训练效果关联性研究.docVIP

FPN1基因多态性与HiHiLo训练后血象指标训练效果关联性研究 　　摘 要： 目的：探讨FPN1基因多态性与HiHiLo训练效果的关联性。方法：选取70名健康受试者在模拟 海拔2 800 m高度进行30 d HiHiLo训练(低氧暴露10 h/d、除白天常氧训练外，以75%V#8226;O?2max强度每周进行3次低氧训练)，测定训练前、训练后第4 d、第7 d、 第16 d、第23 d 和第30 d的RBC、Hct和Hb等血象指标，应用PCR-RFLP方法解析基因多态性。结果：FPN1基因 rs1123110和rs4145237多态性与血象指标的初始值不关联。经30 d HiHiLo训练训练后，rs1 123110位点TT型RBC、Hb、Hct的平均增加量显著高于TC型；TT型Hb、Hct从第7 d、RBC从第1 6 d开始显著增加并持续至第30 d。rs4145237位点GG型RBC、Hb、Hct的平均增加量显著高于 CG型；GG型Hb、Hct、RBC从第16 d开始显著增加，随后持续升高至第30 d。结论：rs112311 0的TT型和rs4145237的GG型与HiHiLo训练效果关联，可以作为预测血象指标训练效果的分子 标记。 　　关键词：膜铁转运蛋白1；基因多态性；高住高练低训；血象指标 　　中图分类号：G804.7 文献标识码：A 文章编 号：1007-3612(2011)05-0048-04 　　Correlative Research on the FPN1 Polymorphism and the Training E ffect of the 　　Hematology Parameters after HiHiLo Training 　　WUYUN Gerile?1，HU Yang?2，YI Long?yan?2，NIE Jing?3，WANG J ing?ling?4，JI Hong?shu?5 　　(1.College of Physical Education，Inner Mongolia Normal Univer sity，HHHOT 010022，Inner Mongolia China； 　　2.Beijing Sport Univer sity，Beijing 100084，China；3.College of Physical Education，Jiangxi Normal Un iversity，Nanchang 330027， 　　Jiangxi China；4.Qingdao Sport Trainin g Center，Qingdao 266023，Shandong China; 　　5.Nanjing Institute of Physica l Education，Nanjing 210014，Jiangsu China) 　　Abstract: Objective: The purpose of this study was to investigate association between FPN1gene polymorphism and effect of HiHiLo training.Methods: Seventy health subjec ts completed thirty?day HiHiLo program at the mock height of 2800m above the se a level (hypoxia exposure 10hr every day，trained in the hypoxic environment 3 t imes with 75%VO?2max every week，and trained at sea level everyday)，and physio lo gical parameters，such as RBC，Hct，Hb，were tested before the training and the4th，7th，16th，23rd，30th day after the training.Gene polymorphisms were analy zed by PCR?RFLP.Results: There was no significant difference on the baseline o f hematological parameters with rs1123110 and rs4145237 polymorphism either.Ave rage increase of RBC，Hb and Hct with TT genotype was si