Evaluation of Aortic Coarctation with 4D Magnetic Resonance Imaging主动脉缩窄的四维磁共振成像评价.pptVIP

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Evaluation of Aortic Coarctation with 4D Magnetic Resonance Imaging主动脉缩窄的四维磁共振成像评价.ppt

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Evaluation of Aortic Coarctation with 4D Magnetic Resonance Imaging主动脉缩窄的四维磁共振成像评价

* * * * * * * * Noninvasive Imaging Modalities of Detectionfor Aortic Coarctation-a modeling approach- Cristina Staicu Rod Hose, David Barber, Patricia Lawford EuHeart New Zealand Aortic coarctation Capturing pressure waves in aorta Image registration segmentation 4 3 2 1 Future challenges Aortic Coarctation : Situation in the World Sources: www-fgg.eur.nl/medbib/WHO_world_atlas_of_birth_defects.html connective tissue disorder left ventricular outflow tract obstruction 7th most common congenital heart disease more common in males than in females (2:1) unoperated coarctation has a 90%mortality by age 50 average age of death is at 35 years (if unoperated) commonly found associated with: Bicuspid aortic valve Aortic stenosis Subaortic stenosis Ventricular septal defect Aortic Coarctation : Prevalence, Anatomy and Symptoms Sources: /imagepages/2007/08/01/health/adam/18128Coarctationoftheaorta.html Diagnosis is challenging imaging invasive pressure measurements stress testing (pharmacological) difficult to determine which patients will benefit from treatment Hypothesis image acquisition diagnosis Aortic coarctation Capturing pressure waves in aorta Image registration segmentation 4 3 2 1 Future challenges Sources: /main/products/mri/ Image Acquisition MAGNET GRADIENT COILS RF COIL MAGNET GRADIENT COILS RF COIL PATIENT TABLE RF DETECTOR DIGITIZER PULSE PROG RF SOURCE RF AMP GRADIENT PULSE PROG GRADIENT AMP SHIELD Image Registration Methods alignment by maximization of mutual information object thorax (heart and aorta) nature of transformation rigid non-rigid modalities involved mono-modal multi-modal modality to model patient to modality subject intra-subject inter-subject atlas optimisation procedure parameters searched for parameters computed interaction interactive semi-automatic automatic Spacing (Sy) Spacing (Sx) Origin (Ox, Oy) Pixel region Pixel value [0,6] [0,5] [0,4] [0,3] [0,1] [0,2] [5,0] [4,0] [3,0] [2,0] [1,0] [