室内氡暴露致儿童白血病病例对照研究.docVIP

室内氡暴露致儿童白血病病例对照研究 　　[摘要] 目的探讨室内氡暴露与儿童白血病之间的关系,为儿童白血病的防治提供依据。方法采用1?2配比病例对照研究方法,病例组为南华大学三所附属医院儿科或血液病科于2006年7月～2008年6月确诊的56例儿童白血病患者,对照为该院与病例同期住院的112例其他非血液系统性疾病、非肿瘤疾病患者。结果客厅和儿童居室氡浓度与儿童白血病有统计学联系,其联系强度OR值(OR 95% CI)分别为3.08(2.16～5.54)与3.73(1.55～8.98)。结论室内高浓度氡暴露可致儿童白血病的发病概率增加。 　　[关键词] 氡暴露;儿童白血病;病例对照研究 　　[中图分类号] R733 [文献标识码] A [文章编号] 1673-9701(2010)04-50-02 　　 　　Leukemia in Children Caused by Indoor Radon Exposure:A Case- control Study 　　LONG Liliang1LI Fenghua1ZHAO Ying1SUN Huiqin2 　　1.Department of Epidemiology and Health Statistics, School of Public Health, University of South China(Nanhua University), Hengyang 421001,China;2. Department of Oncology,The Nanhua Hospital Affiliated to Nanhua University,Hengyang 421000,China 　　 　　[Abstract] Objective To explore the relationship between the indoor radon exposure and leukemia in children in an attempt to provide scientific basis for making preventive measures of childhood leukemia. Methods Fifty-six cases and 112 controls from three affiliated hospitals of University of South China(Nanhua University)were investigated by using 1:2 matched case-control study design from July. 2006 to June 2008. Results There was a significant statistical correlation between the radon concentration in living room or childrens bedroom and childhood leukemia,and their odds ratios were 3.08(OR 95% CI=2.16～5.54)and 3.73(OR95%CI=1.55～8.98),respectively. Conclusion Indoor radon exposure may increase the risk of leukemia in children. 　　[Key words] Exposured of radon;Childhood leukemia;Case-control study 　　白血病是儿童最常见的一种恶性肿瘤,一般以2～7岁的儿童发病率为最高,且在14岁以下儿童恶性肿瘤死亡率中居第一位。白血病难以根治,还可能引起长期后遗症、儿童心理创伤和严重的家庭经济负担。人类白血病的确切病因与发病机理至今未明,多数学者认为白血病是多种因素联合作用的结果,因而缺乏有针对性的病因预防手段。放射性氡(Rn)及氡子体对人类的致???效应越来越引起人们的关注。目前,国际癌症研究机构(IARC)已将氡及其子体划为Ⅰ类致癌因素,WHO也把它们作为19种已知的人类重要致癌因子之一,也是我国规范控制对人体健康影响较大的五种室内环境污染物之一。氡照射可引起肺癌,但是否可诱发白血病迄今尚无定论。本文旨在采用病例对照研究方法,探讨室内氡暴露与儿童白血病的关系,为儿童白血病的防制提供科学依据。 　　1对象与方法 　　1.1对象 　　按照全国小儿血液病会议制定的儿童白血病诊疗标准,选择56例于2006年7月～2008年6月在南华大学三所附属医院儿科或血液病科确诊的白血病患儿为研究对象