胰高血糖素样肽―类似物利拉鲁肽联合二甲双胍治疗对型糖尿病胰岛功能及胰岛β细胞的影响分析.docVIP

胰高血糖素样肽―1类似物利拉鲁肽联合二甲双胍治疗对2型糖尿病胰岛功能及胰岛β细胞的影响分析 关键字：胰高血糖素,高血糖,高血糖素,类似,利拉鲁肽,联合,二甲双胍,治疗,糖尿病,胰岛,功能,胰岛,β细胞,影响,分析 胰高血糖素样肽―1类似物利拉鲁肽联合二甲双胍治疗对2型糖尿病胰岛功能及胰岛β细胞的影响分析 本文为Word文档，感谢你的关注！ 　　【摘要】 目的：分析胰高血糖素样肽-1类似物利拉鲁肽联合二甲双胍对2型糖尿病胰岛功能及胰岛β细胞的临床效果。方法：选取2015年6月-2016年2月本院就诊的48例2型糖尿病患者，在原有二甲双胍治疗的基础上联合应用胰高血糖素样肽-1类似物治疗，比较分析联合用药对2型糖尿病患者胰岛功能及胰岛β细胞的影响。结果：治疗4周后，患者空腹血糖、糖化血红蛋白均低于治疗前（P0.05）；治疗12周后，患者HOMA-B指?滴?67.88±10.27，高于治疗前的44.01±11.72，差异有统计学意义（P0.05）。结论：胰高血糖素样肽-1类似物利拉鲁肽联合二甲双胍对2型糖尿病治疗12周后，患者病情有所改善；另外，患者HOMA-B指数也有所提高，胰岛β细胞的分泌能力有所增强。胰高血糖素样肽-1类似物联合二甲双胍治疗2型糖尿病，在临床中具有推广和应用价值。 　　【关键词】 胰高血糖素样肽-1类似物； 二甲双胍； 2型糖尿病； 胰岛功能； 胰岛β细胞 　　Analysis of Glucagon Like Peptide-1 Analogue Liraglutide Combined with Metformin in the Treatment of Type 2 Diabetes Effect on Islet Function and Islet Beta Cells/ZHANG Li-zhen.//Medical Innovation of China，2017，14（09）：056-059 　　【Abstract】 Objective：To analyze the glucagon like peptide-1 analogue liraglutide combined with metformin in type 2 diabetes clinical effect on islet function and islet beta cells.Method：48 type 2 diabetes patients in our hospital from June 2015 to February 2016，on the basis of metformin treatment were given glucagon-like peptide-1 analogue，the effects of the combination of drugs on pancreatic islet beta cell of patients with type 2 diabetes mellitus were compared and analyzed.Result：After 4 weeks of treatment，fasting blood glucose and HbA1c were lower than before treatment（P0.05）；after 12 weeks of treatment，the HOMA-B index was 67.88±10.27 higher than 44.01±11.72 before treatment，the difference was statistically significant（P0.05）.Conclusion：Glucagon-like peptide-1 analogue combined with metformin in patients with type 2 diabetes after 12 weeks of treatment，the patient’s condition improved；in addition，patients’ HOMA-B index also increased and pancreatic β-cell secreting capacity has been enhanced.Therefore，glucagon-like peptide-1 analogue combined with metformin in the treatment of type 2 diabetes is worthy of clinical application an