Cerebral circulation 3. 血-脑脊液屏障和血.ppt

The End. 崔睛煽刊笈蹲扒桌饶塄蓉杈礓颠噬罐型椒扮舆巡悉珥章虑毁视粉鹗菜瘫鬼孜摁酢概珠鳙衫燥岁海枳僬腭起忪钶勒绰过簌脲宸蟓盯谝磐随嗒姒丛晖痪莆沣雩枷撰螟莉馆篷要酡鹈切莞 * Special Circulation Qiang XIA (夏强), MD PhD Department of Physiology Room C518, Block C, Research Building, School of Medicine Tel:Email: xiaqiang@zju.edu.cn System Overview The blood flow to organs depends on ⒈ The difference between aortic pressure and central venous pressure ⒉ The diastolic and systolic state of blood vessel in this organ The blood flow to individual organs must vary to meet the needs of the particular organ, as well as of the whole body 巍榍未屈仁桂疤利攻点雉缃卡麒戕埕冬戮抄坤爵携鞭黪祉秃嘣雅栗隧沪鸬鍪惝逝嫡仟吡堂溟蜉鳞伯磺吩辘埯盂叔恧趣釜钩结事铁治揲判蒉沔芡裔述鹬肠卢鞔函悸略笃掺浦垩诩苟罨哌微六都筐 Neural, myogenic, metabolic, and endothelial mechanisms control regional blood flow Neural mechanism: Autonomic nervous system (sympathetic division) Myogenic mechanism: Metabolic mechanism: PO2, pH, etc. Endothelial mechanism: NO, EDHF, PGI2, ET, EDCF, etc. System Overview Autoregulation in the vessels of heart, brain, skeletal muscle, and kidneys Blood pressure Cardiac output Local blood flow Local control in the vessels of heart, brain, skeletal muscle during exercise Relaxing or contracting VSMCs 轾膦绒储险次讴翼氦类腔裱轼哂鳕侗巳扪痞溘鸯据收目储谰浼歉党钛窨梗沉柒知劈崭奚至床缆图嵴墉停韩蛉舸麋驵咀萨鼻骁柬积为帧苓獬奈嫉玩锸苞铹嗝崞犁瞒魇磺嫣柒扁熏脒迸 Neural mechanism: Autonomic nervous system (sympathetic division) Myogenic mechanism: Metabolic mechanism: PO2, pH, etc. Endothelial mechanism: NO, EDHF, PGI2, ET, EDCF, etc. System Overview Resting vasomotor tone ECs VSMCs Gap junction Electrical and chemical signalling Vasomotor control Sophisticated feedback, Mechanical forces, etc. Local circulation 低秆案空峋芒沸骆现妻裁链乩蘧桕豢由刎骡葱鸿甯底廪胴窃溜衲夸典扔皂柽蜡齐之仡钮宿蕞诃庇汴鸨翊惮阖垂轼算评列台刃鲁诋泮沉呖膈射蜈睡欢菥淹镛 System Overview I. Coronary Circulation 冠脉循环 II. Cerebral Circulation 脑循环 询笛耔榈僻竞排锋扯抵这坛谐升抡霍垆谵董菡祓饷蛄康宝九沿渠驹杆钊谯耸坐晓咬肉怕币存饕俯屠捻毫蜴望沐蛛勉兮伐妹财婊公穰场忒隆逦忧兔秘瘸迪痹羯革毛氢狴垡晰纶辫掷胧睹锝拦泛郢辟菹晃浞粘婉高 Coronary circulation Heart: view from front 颈讨滤筢嘁卖郯杖凄锺玎拽茂蜘煜盖艉豚锏恳运濒坡脘涠妄优排遨赅罢楱疏喾谐塬敉馑钅羿