代谢综合症预防心脏病的前景.ppt

Focuses of Current Debates in Metabolic Syndrome Clinical Perspectives for MS The Proportion of MS by Different Criteria for Central Obesity Treatment Decision in MS Preventive Perspectives for MS If the components in MS have common pathophysiological pathway ??? Studies of the Association between MS and All-cause Mortality If MS has unique value in prediction of CVD ??? All proposed health project goals are developed and formulated from a health determinant perspective. Determinants of Health Thank you for your attention. * Metabolic Syndrome: A Perspective in Preventive Cardiology Zhao Dong Department of Epidemiology Beijing Institute of Heart, Lung Blood Vessel Diseases Beijing Anzhen Hospital Definitions?????? Etiology and pathophysiology ?????? Clinical importance ??????? Importance for CVD prevention ??????? ● Who are the MS patients ?? (Diagnostic issue) ● Who need the clinical treatment among the MS patients and ?? ● How to treat the MS patients ?? (Treatment issue) ● The effectiveness of treatment strategies??( Treatment issue) Male Female Hypertension High BP High TG Diabetes IFG Central Obesity Low HDL-C Who needs treatment as MS patients? What are the specific targets of treatment for MS patients? ● If the major components of MS have common pathophysiological pathway ??? ● If MS has unique value in prediction of CVD ??? ● How to prevent MS ?? Human obesity …… is due to an excess production of free fatty acids from these lipolytically active depots. This, in turn, might cause hyperinsulinemia via reduced hepatic insulin uptake, followed by peripheral hyper- insulinemia, insulin resistance and, perhaps, diabetes mellitus and hypertension. Bjorntorp P J Clin Hypertension 1986 2:163 …….Thes