抗生素英文课件精品Antibiotic Chemotherapy for Oral Maxillofacial .pptVIP

* Infections with rapid deep spread, resistant to Penn VK, Penn allergic. * Clostridium difficile produces toxin a and b. * * Strict anaerobe=metro * * * * * * * * Don’t give kids/pregnant patients tetracycline Culture and senstivity Amoxicillin okay in pregnant patient. Liver impaired patients no macrolides. * The usual cost on Pen VK prescribe Clindamycin triple the cost. No macrolides when immunocompromised Chlorapenical??? Not forimmune compromised. * Always start with broad spectrum initially. Cidal is first choice, penicillin Static = clindamycin * * * Braod spectrum inviting – opportunistic infections * * * Take advantages of two antibiotics = poor mans augmentin – metronidazole+ penicillin used in perioalot. * Bring patient back to office make sure patient is taking medications. Consider redraining.was a pieceoftooth left behind or a foreign body. * * Staph aureus can develop resistance to penicillin produces beta lactamase enzyme. Primary resistance is natural resistance to drug. Cross resistance one exampleis allergy to penicillin also allergic to cephalosporin. * * Resistance to any antibiotics altered uptake Anaphylactic shock with penicillin Ask patient if allergic to any drugs, ask what kind of reaction they have when taking this. * * Proliferation of bacteria clostridium difficile causes pseudomembranous colitis. * Plasma half life? 2 hours the time is usually 4 times the plasmahalf life dose interval at8 hours, penicillin every 6 hours. Plasma half life is1.5 hours * Metranidazole in alcoholic - puke * Amox and augmentin Hinfluenza makes these a maxillary drug of choice. Almost all exams willhavequestions about this…very important to know which antibiotics do what. * Cidal cell wall synthesis = kiling bacteria 50Sribosomes =static drugs 30 Sribosomes= static drugs. Folic acid – bactrum or spectrum DNA replications * Cephalosporins found by side of gutter????used by heart physicioancs as drug of choice forpremedication.