抗生素PPT课件（英文精品）Antibiotics in Pediatric Dentistry（48p）.pptVIP

Erythromycin Tab: 200/400 mg Sus: 200mg/5ml q.i.d For treatment of mild odont. Inf. In healthy penicillin-alergic patient Clarithromycin Mild odontogenic infections in immunocompromised patients who are allergic to penicillin Sus 125mg/5ml b.i.d Cap 250,500 mg Azithromycin Sus 100mg/5ml Once daily for 5 days Clindamycin Chronic low-grade infections that resistant to Penicillin Erithromycin Cap 150mg Sus 75mg/5ml q.i.d Cephalosporins Bactericidal, low toxicity ,broad spectrum More expensive Effective against oral anaerobic (Staph.,Strep.) some aerobic gram-negative rodes(E coli,proteus,Klebsiella) Cross-sensitivity in 5-15% of patients allergic to penicillin Useful in the penicillin-allergic patient who has compromised host defense Sus Cefalexin 125 or 250 mg/5ml tid Chronic infection ?-lactamase – producing organisms In conjunction with penicillin Sus: 125 mg/5ml, Tab: 250 mg (t.i.d) Metronidazol Average doses recommended for children under 60 i.b (27kg) Actual doses should be based on infection severity, child’s age and renal and hepatic clearances. Antibiotic Usual oral dose Penicillin V Clarithromycin Erythromycin Cephalexin 25-50 mg/kg/day in 4 divided doses 15 mg/kg/day in 2 divided doses 30-40 mg/kg/day in 4 divided doses 25-50 mg/kg/day in 3 divided doses  Perform Surgery Support patient medically Follow up (Confirm treatment response) Infective?endocarditis (previously referred to as bacterial endocarditis) an infection of the hearts inner lining (endocardium) or the heart valves that can damage or even destroy heart valves AHA’s latest guidelines  Published in the Journal of The ADA April 2007 Adverse reactions to antibiotics Drug-resistant bacteria Their hearts are already often exposed to bacteria from the mouth, which can enter their bloodstream during basic daily activities such as brushing or flossing