Basics of Systems Bioinformatics系统生物信息学基础知识(可编辑).docVIP

Basics of Systems Bioinformatics系统生物信息学基础知识 Figure 11 Source G Alterovitz and MF Ramoni eds Systems Bioinformatics An Engineering Case-Based Approach Artech House 2007 Figure 13 Source G Alterovitz and MF Ramoni eds Systems Bioinformatics An Engineering Case-Based Approach Artech House 2007 Figure 14 Source G Alterovitz and MF Ramoni eds Systems Bioinformatics An Engineering Case-Based Approach Artech House 2007 Figure 15 Source G Alterovitz and MF Ramoni eds Systems Bioinformatics An Engineering Case-Based Approach Artech House 2007 Figure 22 Source G Alterovitz and MF Ramoni eds Systems Bioinformatics An Engineering Case-Based Approach Artech House 2007 Figure 21 Source G Alterovitz and MF Ramoni eds Systems Bioinformatics An Engineering Case-Based Approach Artech House 2007 Figure 23 Source G Alterovitz and MF Ramoni eds Systems Bioinformatics An Engineering Case-Based Approach Artech House 2007 RESONANT RECOGNITION MODEL RRM  Prediction of protein hotspotcytochrome C proteins System identification and Analysis Signal processing view of the cell Signal coordination at cell level System view Gene expression A DNA microarray also commonly known as gene chip DNA chip or biochip is a collection of microscopic DNA spots attached to a solid surface such as glass plastic or silicon chip forming an array DNA microarrays such as cDNA microarrays and oligonucleotide microarrays In genetics complementary DNA cDNA is DNA synthesized from a mature mRNA template cDNA is often used to clone eukaryotic genes in prokaryotes Gene expression One sample from a tumor One sample from a normal tissue White – highly expressed under treatment A Gray – no difference Dark - highly expressed under treatment B Time changes – measure drugs in 6 hours cDNA microarrays The procedure begins by attaching the DNA sequences of thousands of genes onto microscope slide in the pattern of spots with each spot