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新视野系列研究生课程：科技论文的构思、撰写和发表 生物医学世纪讲坛 特邀报告： How to Publish Your Papers in the Top Scientific Journals 鲁白教授 What Is a First-Class Paper? Major advance in a classic field 干细胞是如何分化成特定组织细胞的，胆固醇在人体的正常功用 New techniques and methods that can be widely used 人类基因组研究中的自动测序技术 , PCR, Patch clamp Discoveries with obvious practical implications AIDS virus receptor 的发现, 老年痴呆症基因的发现 Conceptual breakthrough, novel ideas 神经营养因子可以促进学习记忆 Challenge to traditional views, break dogma 脑内有可分裂的神经干细胞，打破了传统观念 Opening up new area, cross board “细胞凋亡”现象的发现, 开辟了新的科研领域 What Is a Mediocre Paper? Horizontal growth I made the discovery in rats, you find the same in cat. Filling gaps EGF activates JNK which is known to induce c-Jun expression. You show that EFG enhances c-Jun expression. Working out details I found NO induces the production of cGMP, you work out dose response and time course. Support existing idea, “me too” EGF-R endocytosis requires dynamin, PDGF-R too. Follow up CREB binds to CRE. Working out CRE sequence. Incomplete study, preliminary How to Read Scientific Papers? The Gilbert way Keep these in mind when you read What is the major question addressed in this paper? Is this question important and why? What are the approaches used in this paper, and whether they are adequate for the questions? What are the novel idea or using innovative approaches? What is the concept coming out of this paper? Do the results presented support this new concept? Weekly reading of CNS titles Critical, appreciative Articles? An RNA Thermosensor Controls Expression of Virulence Genes in Listeria monocytogenesJ?rgen Johansson, Pierre Mandin, Adriana Renzoni, Claude Chiaruttini, Mathias Springer, and Pascale Cossart ? Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAiJavier Martinez, Agnieszka Patkaniowska, Henning Urlaub, Reinhard Lührmann, and Thomas Tuschl OcaB Is Required for Normal Transcription and V(D)J Recombination of a Subset of Immunoglobulin ? gen